川芎嗪对严重烫伤大鼠肝组织脂质过氧化影响的探讨  

Studies of the Affection on Lipid-peroxidation from Liver Tissue in Scalded Rat by Tetramethylpyrazine

作　　者：张月[1] 成彩莲[2] 

机构地区：[1]华南农业大学动物科学学院,广州510640 [2]武汉科技大学医学院生物化学教研室

出　　处：《数理医药学杂志》2007年第4期453-455,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨川芎嗪(tetramethylpyrazine,TMP)对烫伤大鼠肝组织脂质过氧化的影响及保护作用。方法:采用大鼠40%体表面积(TBSA)Ⅲ度烫伤模型,通过检测大鼠严重烫伤后肝组织内丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)和超氧化物歧化酶(SOD)的改变,观察川芎嗪对烫伤大鼠的保护作用。结果:40%TBSAⅢ度烫伤后大鼠肝组织内MDA显著升高,GSH-PX和SOD活力显著降低,川芎嗪治疗组大鼠肝组织内MDA含量显著降低,GSH-PX和SOD活力显著升高,与单烫伤组比较各指标均有显著性差异。结论:烫伤后肝组织内脂质过氧化增强,抗氧化能力减弱,川芎嗪具有较强的抗氧化、抗自由基损伤的保护作用。To study the affection and protection for lipid-peroxidation for liver tissue inscalded rats by tetramethylpyrazine. Methods： Using 40% TBSAm degree scalded rat mode, studing the changes of MDA;GSH-PX and SOD in liver tissues to study the protection by tetramethylpyrazine. Results： The result showed that 40% TBSA Ⅲ degree empyrosis resulted in significant increase of MDA and obvious decreases of GSH-PX and SOD activity in liver tissues. The amount of MDA was decreased significantly and the GSH-PX and SOD activity increased apparently after the treatment of tetramethylpyrazine. There were statistical differences of these indexes between the two groups. Conclusion： It was suggested that there were strong lipid-peroxidation and decreases antioxidation in the liver tissue after empyrosis, relatively, tetramethylpyrazine, had strong function of antioxidation and free radical protectiveing.

关 键 词：肝组织 脂质过氧化反应 

分 类 号：R644[医药卫生—外科学]