2型糖尿病合并心律失常患者血脂联素、肿瘤坏死因子-α水平测定及临床意义  

The Measurement of Serum Adiponectin and Tumor Necrosis Factor-alpha Levels in Type 2 Diabetic Arrhythmia and Its Clinical Significance

作　　者：田林红[1] 张明[1] 罗晖[1] 张宏刚[1] 王逸群[1] 倪安民[1] 陈雪红[1] 

机构地区：[1]兰州大学第二医院内分泌科,甘肃兰州730030

出　　处：《中国慢性病预防与控制》2007年第3期239-241,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：甘肃省自然科学基金资助项目(ZS001-A23-078-Y)

摘　　要：目的探讨血脂联素、肿瘤坏死因子-α与2型糖尿病及糖尿病心脏病变的关系。方法采用放射免疫分析法测定60例2型糖尿病血脂联素及肿瘤坏死因子-α水平,经心电图检查,合并心律失常25例为糖尿病合并心律失常组,心电图正常的35例为糖尿病组,22例正常者为对照组。结果糖尿病合并心律失常组血脂联素水平低于糖尿病组及对照组[分别为(12.21±9.06)μg/ml、(18.34±11.17)μg/ml、(20.18±8.76)μg/ml],差别有统计学意义(P<0.05,P<0.01)。糖尿病合并心律失常组及糖尿病组肿瘤坏死因子-α高于对照组[分别为(0.94±0.42)ng/ml、(0.91±0.47)ng/ml、(0.71±0.30)ng/ml],差别有统计学意义(均P<0.05)。结论低脂联素水平与糖尿病心脏病变的发生、发展有关;肿瘤坏死因子-α在糖尿病的发生及糖尿病心脏病变的形成中有一定作用。Objective To explore the relationship of adiponectin （APN）, tumor necrosis factor-alpha （TNF-α） with diabetic arrythmia. Methods Sixty patients with type 2 diabetic mellitus （DM） were divided into DMA group （n=25, ECG showed cardiac arrhythmia） and DM group （n=35, ECG showed normal）. Twenty-two healthy people were as control. Their serum APN, TNF-α were tested with radioimmunoassay. Results Serum APN level in DMA was lower than that in control and DM group [（12.21±9.06） vs （20.18±8.76） and （18.34±1.17） μg/ml, P〈0.01, P〈0.05]; Serum TNF-α was higher in DMA and DM group than in control group [（0.94±0.42）and （0.91±0.47） vs （0.71±0.30） ng/ml, P〈0.05, P〈0.05]. Conclusion There was a relation between Hypoadiponectinemia and the occurrence ＆ development of diabetic cardiac disease; The TNF-α may affect the occurrence of type 2 DM and the form of diabetic cardiac arrythmia.

关 键 词：糖尿病 2型 心律失常 脂联素 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]