新型掺铕多孔磷灰石/硅灰石磁性生物活性玻璃陶瓷的研究  

A Novel Europium Doped Apatite/Wollastonite Porous Magnetic Bioactive Glass Ceramic

作　　者：张王志[1] 周大利[1] 杨为中[1] 尹光福[1] 欧俊[1] 

机构地区：[1]四川大学材料科学与工程学院,成都610064

出　　处：《生物医学工程学杂志》2007年第4期785-789,共5页Journal of Biomedical Engineering

基　　金：国家863计划资助项目(2002AA326080)

摘　　要：通过溶胶-凝胶工艺制备了一种掺铕磷灰石/硅灰石多孔磁性生物活性玻璃陶瓷材料。采用DTA、XRD、SEM、能谱(Energy dispersive spectroscopy,EDS)、诱导耦合等离子体原子发射光谱(Inductive couple plasma atomic emission spectrometry,ICP-AES)、振动磁强计(Vibrating sample magnetometer,VSM)等方法分析材料的制备工艺、晶相组成、显微结构、磁性、生物活性和降解性。结果表明:材料的主晶相除了包括氟氧磷灰石、β-硅灰石相外,掺入的稀土元素Eu进入硅酸钙晶核内部形成Ca2Eu8(SiO4)6O2物相。当Eu2O3的掺入量为2%(质量百分比)时,充磁至10000Oe材料的饱和磁化强度达到2.18emu/g。材料在模拟体液(Simulated body fluid,SBF)中浸泡,短期内可在表面形成羟基磷灰石层,显示出良好的生物活性。是一类十分具有发展潜力的骨修复材料、骨组织工程支架材料及骨癌的热治疗修复材料。A new biocompatible apatite-wollastonite magnetic glass ceramic has been synthesized via sol-gel process. Characteristics of the materials were determined with differential thermal analysis （DTA）, X-ray diffraction （XRD）, scan electron microscopy （SEM）, energy dispersive spectrum （EDS）, inductively couple plasma atomic emission spectroscopy （ICP-AES） ,vibrating sample magnetometer （VSM） and so on. Results showed that the main crystalline phases of the material were hydroxyapatite/fluoroapatite [Ca10（PO4）6（OH, F））, β-wollastonite[β-CaSiO3] and calcium europium oxide silicate Ca2Eu8[（SiO4）6O2], The magnetization of the sample contanining 2% Eu2O3 in weight reached 2.18 emu/g for an applied field of 10 000Oe. Hydroxyapatite layer could form on the surface of the sample while soaking for 14 days in simulated body fluid, Good bioactivity was demonstrated, So it is a potential bone repairing material as well as a hyperthemia treatment material for pateints with cancer.

关 键 词：生物材料 磁性 玻璃陶瓷 铕 

分 类 号：R318.08[医药卫生—生物医学工程]