制备工艺对骨组织支架材料聚磷酸钙降解性能的影响研究  

Effect of Processing Parameters on the Degradation of Calcium Polyphosphate Bioceramic for Bone Tissue Scaffolds

作　　者：秦滢杰[1] 余喜讯[1] 陈元维[1] 丁玉龙[1] 万昌秀[1] 

机构地区：[1]四川大学高分子科学与工程学院,成都610065

出　　处：《生物医学工程学杂志》2007年第4期794-797,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30370411;50472091)

摘　　要：通过对不同工艺参数的聚磷酸钙(CPP)多孔支架材料在三羟甲基氨基甲烷溶液(Tris)和模拟体液(SBF)中降解的比较研究,探索影响CPP降解的因素。采用不同的煅烧温度和烧料粒径制备了不同主晶型的CPP多孔支架材料,并在Tris缓冲液和SBF模拟体液中进行降解实验,时间为60d。X衍射谱检测CPP的结构,磷酸根浓度法检测CPP的降解速率。结果表明:三种晶型CPP的降解速率不同,α-CPP的降解速率最慢;煅烧温度越低,粒径越小,降解速度越快。制备工艺对CPP支架材料的降解规律有显著影响。This study was undertaken to elucidate the degradation regularity of calcium polyphosphate （CPP） scaffolds with different preparation parameters. CPP scaffolds with different main crystalline phases were prepared by controlling the particle size of the calcining stuff and the calcining heat. Specimens were soaked into Tris-buffer solution and simulated body fluid （SBF） for 60 days. Results show.α-CPP degrades faster than does β-CPP, and CPP degrades faster than does β-CPP; the lower the sinter temperature, the better the degradation of CPP; morever,the degradation rate of CPP is inversely proportional to the original particle size. These data suggest that crystal type,sinter temperature and particle size influence the degradation rate of CPP markedly.

关 键 词：聚磷酸钙 制备 降解 

分 类 号：R318.08[医药卫生—生物医学工程]