眼血散方对实验性玻璃体积血兔眼玻璃体液中IL-1β的影响  

The Effect of Yanxuesan Formula on IL-1β in the Eye Vitreous Humor of the Experimental Rabbits of Vitreous Hematocele

作　　者：曾巍[1] 刘晓年[1] 周鲜琳[1] 周峻[1] 孙江桥[1] 

机构地区：[1]湖北中医学院,湖北武汉430065

出　　处：《湖北中医学院学报》2007年第2期8-10,共3页Journal of Hubei College of Traditional Chinese Medicine

基　　金：湖北省自然科学基金项目;[2004ABA175]

摘　　要：目的观察眼血散方对实验性玻璃体积血兔眼玻璃体液中IL-1β的影响,分析研究眼血散对玻璃体积血的促吸收作用及对积血所致增殖性玻璃体视网膜病(PVR)防治作用。方法给玻璃体积血模型兔灌服大、中、小剂量眼血散复方制剂,并设模型对照组和空白对照组,分别于用药后3、6周观察各组的玻璃体积血情况,并于用药后6周检测各组兔玻璃体液中IL-1β含量。结果各药物治疗组玻璃体积血程度均轻于模型对照组,经比较有显著性差异或极显著性差异(P<0.05或P<0.01);各药物治疗组IL-1β含量均低于模型对照组,其中大、中剂量组与模型对照组比较有极显著性差异(P<0.01)。结论眼血散方可促进玻璃体积血的吸收,并能通过抑制IL-1β的生成防治PVR。Objective： To observe Yanxuesan Fonnula＇s effect on IL - 1β in the eye vitreous humor of the experimental rabbits of vitreous hematocele and study Yanxuesan formula＇s absorbefacient effect on vitreous hematocele and its preventive effect on PVC caused by.hematocele. Methods： The model rabbits of vitreous hematocele are fed by Yanxuesan Formula of big, medium and small dosages so as to set up model group and control group. The situation of vitreous hematocele in the third and sixth week is observed respectively and content of vitreous humor of the rabbit groups will be examined in the 6th week. Results ： The vitreous humor degree of the treated group is lighter than that of the control group, there exists significant difference or extremely significant difference through the comparison （P 〈 0. 05 orP 〈 0. 01 ） ; The content of IL - 1βof the treated groups is respectively lower than the control group. There exists significant and extremely significant difference between the groups fed by large dosage and medium dosage formula and the control group （P 〈 0. 01 ）. Conclusions： Yanxuesan Formula can promote the absorbing of vitreous hematocele and prevent PVR by inhibiting the formation of IL - 1β.

关 键 词：眼血散 玻璃体积血 炎性因子 IL-1Β 

分 类 号：R285.5[医药卫生—中药学]