胎脑组织移植对额叶皮层损伤大鼠辨别学习、记忆之影响  

Effects of implanting embryonic brain tissue on learning and memory of discrimination performance in rats with frontal cortexes lesions

作　　者：吴佐泉[1] 李德忠[1] 马廉亭[2] 徐国政[2] 龚杰[2] 杨铭[2] 王溶杨 郑宝轩 

机构地区：[1]广州军区武汉总医院医学实验中心,武汉430070 [2]广州军区武汉总医院神经外科,武汉430070 [3]解放军第181医院

出　　处：《中华器官移植杂志》1997年第1期42-44,共3页Chinese Journal of Organ Transplantation

基　　金：广西壮族自治区自然科学基金

摘　　要：为观察胎脑组织移植对双侧额叶皮层损伤大鼠学习、记忆功能的影响，对大鼠模型行股脑组织移植。学习、记忆再观测验在Y型迷宫中进行。大鼠学习和记忆成绩以测验时达到10次电击均为正确反应时所需的电台次数表示。结果显示，股脑组织移植能显著减少达到上述标准所需的电击次数，且移植3个月较移植10天的动物达到上次标准所需的训练次数减少更明显。组织学检查揭示，移植的神经组织不仅存活，分化良好，而且与宿主脑之间有部分融合。结果表明，胎脑组织移植能促进双侧额叶皮层损伤大鼠学习、记忆功能的恢复，并提示移植3～6个月后移植物与宿主脑之间可形成部分纤维连接。Effects of transplantation of fetal brain on learning and memory of discrindnation performance were observed in the rats with damage to bilateral cortexes. The rats were placed on an electrified grid in a Y-maze and learned to run into the light arm (safe area). The criterion of learning or memory retrieval was met after the animals had correctly made 10 of 10 consecutive choices. The results showed that implanting fetal brain tissue into the damaged frontal cortexes of the rats had caused a significant decrease in the number of trials needed to meet the criterion. The decrease in the number of trials needed to meet the criterion in the rats which began behavioral training 3 mouths after transplantation was more obvious compared to that in the rats which began the training 10 days following transplantation. Histological examination revealed that implanted brairi tissue with well-differentiation survived and that there were merges betweeh the graft and host brain in some areas 3 or 6 months after transplantation. Our results showed that the transplantation of embryonic brain tissue could promote recovery of learning and memory retrieval of visual discrimination in the rats with damage of bilateral frontal cortexes and that connections between the brain tissue implants and host brain tissue could develop.

关 键 词：额叶损伤 脑组织移植 胎脑组织 学习 记忆 

分 类 号：R651.11[医药卫生—外科学]