胎脾移植治疗血友病甲五例报告  

Fetal splenic transplantation for the treatment of Hemophilia A: a preliminary report of 5 cases

作　　者：李荣[1] 高焱明[1] 衡明惇 彭心宇[2] 王淑玲[2] 王桂芬[2] 

机构地区：[1]广东湛江中心人民医院,524037 [2]石河子医学院附属第一医院外科

出　　处：《中华器官移植杂志》1997年第1期45-46,共2页Chinese Journal of Organ Transplantation

摘　　要：为探讨胎脾移植治疗血友病的效果，对5例血友病甲患者施行了胳膊移植术。供你为胎龄为8个月以上的水囊引产死胎，移植物为脾脏连同部分胰腺，供体门静脉、腹腔动脉与受者冒网膜右动、静脉吻合。术后行B型超声波、彩色多普勒、凝血因子（Ⅷ：C）水平监测。结果1例术后21天因陈旧性腹膜后血肿感染死亡，1例失访，1例随访24个月，移植脾增大，Ⅷ：C上升。2例分别于术后6个月、12个月失去功能。研究结果提示术后近期均显一定效果．若能解决排斥等问题，此法可望成为治疗血友病甲的有效方法。The therapeutic efficacy of fetal splenic transplantation for the treatment of hemophilia A was investigated. The spleen with partial pancreas was taken out from fetal cadavers of 8 or more months after artificial induction of labor by water bag. The celiac artery and portal vein were anastomosed to the right gastroepiploic artery and veins of the recipients. 5 allotransplantation were per formed in 5 cases of severe hemophilia A. All patients were monitored after operation by using B-mode ultrasound, color Duplex scanner and by determination of plasma levels of factor Ⅷ: C. Patient 1 died of infection of remote retroperitoneal hematoma 21 days after the operation and patient 2 failed to finish the follow-up. The patient 3 had enlarged spleen and elevated level of factor Ⅷ: C 24 hours after surgery. Transplants in the remaining two patients lose functions 6 and 12 months, respectively, after transplantation. Our results suggested that if problem of rejection could be resolved, the fetal splenic transplantation would be an effective treatment for hemophilia A.

关 键 词：脾移植 血友病 胎脾移植 治疗 

分 类 号：R657.605[医药卫生—外科学] R554.105[医药卫生—临床医学]