山醇提取物治疗实验性脑梗塞  

Treatment of experimental cerebral infarction by alcoholic extract of piper hancei (PHE)

作　　者：秦新月[1,2] 王伟[1,2] 董为伟[1,2] 

机构地区：[1]重庆医科大学临床医学院神经内科神经病学研究所 [2]同济医科大学

出　　处：《卒中与神经疾病》1997年第2期57-59,共3页Stroke and Nervous Diseases

摘　　要：采用光化学诱导法建立Ｗｉｓｔａｒ鼠大脑中动脉闭塞脑缺血模型，应用具有强力血小板活化因子（ＰＡＦ）受体拮抗作用的中药山醇提取物治疗实验性脑梗塞，通过局部脑血流量（ｒＣＢＦ）、脑组织含水量、血浆粘度及脑组织超微结构改变等指标观察，发现山醇能改善缺血区脑组织的ＣＢＦ，减轻脑水肿，降低血浆粘度，减轻缺血后神经元线粒体的肿胀，减少核的坏死溶解。Alcoholic extract of Piper hancei(PHE) which is of a role of Plateiet activation factor receptor antagonist was applied to treat the experiment rat cerebral ischemia induced by photochemical occlusion of middle cerebral artery. The results showed that the PHE could elevate the rCBF in ischemic region, reduce the cerebral edema and the plasma viscosity, and relieve the ischemic neuronal necrosis. The authors suggested that the PHE had an effect on cerebral protection in experimental cerebral infarction.

关 键 词：脑梗塞 山Ju醇提取物 中药 

分 类 号：R277.733.3[医药卫生—中医学]