细胞因子对PMSG-hCG诱发未成年小鼠排卵的影响  

EFFECT OF CYTOKINES ON PMSG-hCG INDUCED OVULATION BY IMMATURE FEMALE MICE

作　　者：李雪岩[1] 彭如心[1] 张业[1] 孟庆芳[1] 吕桂敏 

机构地区：[1]齐齐哈尔医学院生理学教研室 [2]唐山市路南医院

出　　处：《齐齐哈尔医学院学报》1997年第2期81-82,共2页Journal of Qiqihar Medical University

基　　金：黑龙江省自然科学基金资助课题

摘　　要：本实验观察了肿瘤坏死因子-a(TNF-a)、白介素-1(IL-1)、白介素-2(IL-2)对PMSG-hCG诱发未成年小鼠排卵的影响。发现TNF-a和白介素-2对PMSG-hCG诱发未成年小鼠排卵有显著的促进作用。IL-1对PMSG-hCG诱发未成年小鼠排卵有显著的抑制作用。We investigated the effect of tumor necrosis factor-a (TNF-a) and inter- leukin (IL)-1 and IL-2 on pregnancy-mare-sera-gonadotropin (PMSG)-hCG stimulated ovulation of immature female mice. Results are that TNF-a and IL-2 promote significantly PMSG-hCG induced ovulation. The effect was dose-department.But IL-1 inhibited PMSG-hCG induced ovulation.

关 键 词：肿瘤坏死因子 白介素-1 白介素-2 排卵 HCG 

分 类 号：R339.22[医药卫生—人体生理学] Q492.5[医药卫生—基础医学]