代谢综合征对原发性高血压患者颈动脉结构和功能的影响  

Effects of metabolic syndrome on the structure and function of carotid artery in patients with essential hypertension

作　　者：杨霞[1] 林金秀[1] 陈达光[1] 

机构地区：[1]福建医科大学附属第一医院心内科,福州350005

出　　处：《中华老年心脑血管病杂志》2007年第8期515-517,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的观察代谢综合征(MS)对原发性高血压(EH)患者颈动脉结构和功能的影响。方法将156例EH患者根据是否合并MS,分为EH+MS组(61例)和EH+非MS组(95例),同期选择31例健康体检者为对照组(NC组),超声测定颈动脉内径、颈动脉内膜中层厚度(IMT)、舒张末期血流速度及僵硬度等。结果EH+MS组颈动脉内径及IMT明显高于EH+非MS组和NC组(P<0.05),舒张末期血流速度明显低于后2组(P<0.05)。颈动脉僵硬度高低排序为EH+MS组>EH+非MS组>NC组。IMT、平均流速-时间积分与年龄、收缩压、体重指数的相关性较强。结论MS促进EH患者动脉硬化的发展。Objective To investigate the effects of metabolic syndrome（MS） on the structure and function of carotid artery in patients with essential hypertension （EH）. Methods 156 patients with EH were assigned to two groups： EH with MS （EH＋MS） group, EH without MS （EH＋nonMS） group. Thirty-one healthy subjects constituted the normal control （NC） group. The inner diameter, intima-media thickness （IMT）, blood flow rate at the end phase of dilatation, rigidity of carotid artery,etc, were measured by Doppler ultrasonography. Results The inner diameter of carotid artery and IMT were significantly higher in EH ＋MS group than in EH ＋ nonMS group and NC group（ P 〈0.05）. The blood flow rate at the end phase of dilatation was significantly lower in EH＋MS group than in EH＋nonMS group and NC group（ P 〈0.05）. The rigidity of carotid artery was EH＋MS group 〉 EH＋nonMS group 〉 NC group. Both IMT and time-average velocity product were highly related with age, systolic blood pressure and body mass index. Conclusion Metabolic syndrome promotes the arteriosclerotic development in patients with essential hypertension.

关 键 词：高血压 代谢疾病 颈动脉 动脉硬化 

分 类 号：R589[医药卫生—内分泌] R544.1[医药卫生—内科学]