慢性肺心病患者的血浆BNP变化分析  

Patients with Chronic Pulmonary Heart Disease in Plasma BNP Analysis

作　　者：王灿良 曾维新[1] 

机构地区：[1]广州市花都区人民医院,广东广州510800

出　　处：《河北医学》2007年第8期933-935,共3页Hebei Medicine

摘　　要：目的:探讨慢性肺心病(PHD)患者血浆脑钠素(BNP)的水平及临床意义。方法:PHD患者40例,分为急性加重期和缓解期;对照组30例,采用放射免疫分析法分别测定各组的BNP、血管内皮素—1(ET-1)测定动脉血氧分压(PaO2),通过彩色超声心动图测定计算肺动收缩压(SPpa),各组进行比较。结果:(PHD)组两期BNP均高于对照组(P<0.05),且血浆BNP水平与ET-1、SPpa呈正相关,与PaO2呈负相关(均P<0.05)。结论:BNP参与了PHD的病理生理过程,可用于判断是否由PHD引起的呼吸困难。Objective： On chronic pulmonary heart disease （PHD） plasma brain natriuretic peptide （BNP） levels and clinical significance. Methods ：40 PHD patients were divided into acute exacerbation and remission; The control group of 30 patients. RIA analysis were measured in each group of BNP, Vascular endothelin - 1 （ ET - 1 ） in arterial partial pressure of oxygen （ PaO2 ） , through color echocardiography calculation of the pulmonary artery systolic pressure （SPpa）, the groups were compared. Results： （PHD） Group 2 BNP were higher （ P 〈 0.05 ）, and the plasma level of BNP with the ET - 1, SPpa positively correlated, and PaO2 was negatively correlated （ all P 〈 0.05 ）. Conclusion： BNP and PHD in the pathophysiological process can be used to determine whether the PHD caused by the difficulty in breathing.

关 键 词：肺心病 血浆脑钠素 血管内皮素-1 

分 类 号：R541.5[医药卫生—心血管疾病]