Effects of minimal lipopolysaccharide-instilled lungs on ventilator-induced lung injury in rats  

作　　者：LI Ke-zhong WANG Qiu-jun SUN Tao YAO Shang-long 

机构地区：[1]Department of Anesthesiology, Second Hospital of Shandong University, Jinan 250033, China [2]Department of Anesthesiology , Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, China [3]Department of Pain Management, Shandong Provincial Hospital, Jinan 250021, China

出　　处：《Chinese Medical Journal》2007年第16期1451-1453,共3页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.30471661);Shandong Provincial Natural Science Foundation(No.Y2006C120)

摘　　要：Mechanical ventilation （MV） may aggravate lung injury induced by a variety of injuries, including intratracheal hydrochloric acid instillation, intratracheal lipopolysaccharide （LPS） instillation with or without concurrent saline lavage, intravenous LPS, or intravenous oleic acid. However, the mechanism for this detrimental effect of MV is unclear. The purpose of the present study was to determine the effect of MV on lung injury induced by minimal LPS-instillation and on the LPS receptor CD14 in the lung.Mechanical ventilation （MV） may aggravate lung injury induced by a variety of injuries, including intratracheal hydrochloric acid instillation, intratracheal lipopolysaccharide （LPS） instillation with or without concurrent saline lavage, intravenous LPS, or intravenous oleic acid. However, the mechanism for this detrimental effect of MV is unclear. The purpose of the present study was to determine the effect of MV on lung injury induced by minimal LPS-instillation and on the LPS receptor CD14 in the lung.

关 键 词：mechanical ventilation lung injury LIPOPOLYSACCHARIDE 

分 类 号：R563[医药卫生—呼吸系统]