L-精氨酸调节缺氧性肺动脉增压反应的实验研究  

AN EXPERIMENTAL STUDY ON MODULATORY EFFECT OF L-ARGININE ON HYPOXIC PULMONARY ARTERY PRESSOR RESPONSE

作　　者：杜军保[1] 赵斌[2] 黎文[2] 李万镇[1] 张前进[3] 

机构地区：[1]北京医科大学第一医院儿科 [2]北京积水潭医院内科 [3]北京医科大学第一医院中医科,100034

出　　处：《北京医科大学学报》1997年第2期136-137,共2页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金!39470735;卫生部优秀青年科技人才专项基金

摘　　要：目的：探讨L-精氨酸（L-arg）对缺氧性肺动脉增压反应的调节作用。方法：将Wistar大鼠（n=18）随机分为对照组、缺氧组（O2=10％±0．5％）及缺氧加L-arg组[L-arg500ms／（ks·d）腹腔注射]。经右心导管法测定各组大鼠肺动脉压力，并经分光光度法间接测定血浆一氧化氮含量。结果：缺氧组大鼠肺动脉平均压明显高于对照组，其血浆一氧化氮含量降低；缺氧加L-arg组大鼠肺动脉增压反应受到抑制，其血浆一氧化氮含量升高。结论：L-arg通过促进体内一氧化氮生成，对缺氧性肺动脉增压反应起重要的调节作用。Objective: To study the modulatory effect of L-arginine (L-arg) on hypoxic pulmonary pressor response. Methods: Eighteen Wistar rats were randomly divided into hypoxia group (O2=10% ±0.5% ), hypoxia with L-arg group (L-arg 500 mg. kg-1· d-1) and control group. Pulmonary artery pressure of each rat was evaluated by using a right cardiac catheterization procedure and indirect plasma concentration of nitric oxide was measured via spectrophotomery. Results: Pulmonary artery mean pressurewas significantly increased in rats exposed to two-week hypoxia. Meanwhile, indirect plasma nitric oxide concentration was markedly decreased compared with controls. Hypoxic pulmonary pressor responsewas attenuated with an increase in plasma nitric oxide level in L-arg treated rats that were exposed totwo-week hypoxia. Conclusion: L-arg plays an important role in modulating hypoxic pulmonary pressorresponse through initiating nitric oxide synthesis in rats.

关 键 词：精氨酸 高血压 肺性高血压 药物疗法 

分 类 号：R544.105[医药卫生—心血管疾病] R977.4[医药卫生—内科学]