实验性高脂血症对阿霉素肾病鼠的加速肾毒作用  

EXACERBATION OF NEPHROTOXICITY IN ADRIAMYCIN-INDUCED NEPHROTIC RATS BY EXPERIMENTAL HYPERLIPIDEMIA

作　　者：姚勇[1] 徐国宾[2] 张英[1] 杨霁云[1] 朱丽华[2] 

机构地区：[1]北京医科大学第一医院儿科 [2]北京医科大学第一医院检验科,100034

出　　处：《北京医科大学学报》1997年第2期139-141,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：观察实验性高脂血症对肾病鼠的肾毒性作用。方法：阿霉素肾病鼠随机分为两组，分别饲以高脂饲料和普通饲料，测定其血脂，肾功能、尿蛋白和肾皮质SOD，并进行肾组织学观察。结果：肾病高脂饮食组与肾病对照组比较，2周后血胆固醇、甘油三酯明显升高，8周后肌酐清除率和肾皮质SOD水平明显下降。结论：过量的脂质可加速肾病时肾损伤且与自由基代谢失衡有关。Objective:The effect of experimental hyperlipidemia on nephrotoxicity of nephrotic rats wasstudied. Methods: Adriamycin-induced nephrotic rats were randomized into 2 groups, feeding with hyperlipidic diet or general diet. The plasma lipids, renal function, protein in urine and SOD in renal cortex were measured. The renal morphological change was observed. Results: In hyperlipidic diet group,the plasma cholesterol and triglyceride elevated significantly after 2 weeks (p<0. 05), the creatinineclearance rate and the level of SOD in renal cortex were decreased significantly after 8 weeks (p<0. 05).Conclusion: Overload of lipid can induce the progression of renal injury in nephrotic syndrome which isalso related with the abnormal metabolism of oxygenic free-radical.

关 键 词：高脂血症 肾病综合征 阿霉素 

分 类 号：R692.02[医药卫生—泌尿科学] R589.206[医药卫生—外科学]