两性霉素B的毫微球与注射剂的急性毒性和体内抗感染试验比较  

THE COMPARISON OF ACUTE TOXICITY AND ANTIBACTERIAL EFFECT IN VIVO OF AMPHOTERICINUM B MICROGLOBE AND ITS INJECTION

作　　者：韩五成 韩玉 郭平[3] 

机构地区：[1]四川省药品检验所,成都610036 [2]成都制药九厂,成都610072 [3]华西医科大学药学院,成都610041

出　　处：《华西药学杂志》1997年第2期97-98,共2页West China Journal of Pharmaceutical Sciences

摘　　要：在平行条件下，测得两性霉素B毫微球及注射用两性霉素B的LD(50)分别为（26．5±4．4）mg／kg、（3．22±0．68）mg／kg；ED(50)分别为（1．00±0．27）mg／kg、（0．69±0．16）mg／kg；TI分别为27和5。In the same condition, the LD(50),ED(50) and TI of amphotericinum B microglobe and amphotericinum B injection were determined and their results were obtained as follow: LD(50)(26.5±4.4)mg/kg and (3. 22±0. 68)mg/kg respectively, ED(50):(1. 00 ± 0. 27)mg/kg and (0. 69 ± 0. 16)mg/kg respectively, TI: 27 and 5 respectively.

关 键 词：两性霉素B 毫微球 注射 毒性 体内抗感染 

分 类 号：R978.5[医药卫生—药品] R944[医药卫生—药学]