KMnO_4-Na_2SO_3化学发光体系测定对乙酰氨基酚  

Determination of paracetamol by flow-injection chemiluminescence with KMnO4-Na2SO3 system

作　　者：熊迅宇[1] 唐玉海[1] 王楠楠[1] 武世界[2] 

机构地区：[1]西安交通大学分析科学研究所,西安710061 [2]兰州大学化学系,兰州730000

出　　处：《分析试验室》2007年第2期80-83,共4页Chinese Journal of Analysis Laboratory

摘　　要：在酸性条件下,对乙酰氨基酚对KMnO4-Na2SO3体系发光反应具有明显的增敏作用,据此建立了流动注射化学发光测定对乙酰氨基酚的新方法。在该发光体系中,对乙酰氨基酚在1.0×10-8-1.0×10^-5g/mL范围内与发光强度呈良好的线性关系,检出限（3R）为2.0×10^-9g/mL,对对乙酰氨基酚进行11次平行测定,其相对标准偏差为2.6%。本方法应用于片剂中对乙酰氨基酚的测定,并与药典方法进行对照。In the H2 SO4 solution, paracetamol could enhance obviously the chemil （CL） intensity of the reaction of KMnO4 - Na2 SO3 system. So, a new flow-injection CL method for the determination of paracetamol has been developed. The linear range of this method is 1.0×10^-8 - 1.0×10^-5 g/mL for paracetamol with the detection limit of 2.0 × 10^-9 g/mL and the RSD% is 2.6%. The method is simple, rapid, and sensitive, and it has been applied to the determination of paracetamol in pharmaceutical tablets with satisfactory results.

关 键 词：流动注射 化学发光 对乙酰氨基酚 KMNO4 Na2SO3 

分 类 号：O657.3[理学—分析化学]