开玛系统揭示的失血性休克家兔对间羟胺反应的个体差异性(英文)  

The Individual Reactivity to Metaraminol in Rabbits with Experimental Hemorrhagic Shock Revealed by CAIMA System

作　　者：周冠杯 王关炎[1] 金正均[1] 喻中城[2] 

机构地区：[1]上海第二医科大学药理教研室,200025 [2]上海第二医科大学附属瑞金医院急诊科,200025

出　　处：《上海第二医科大学学报》1997年第3期232-236,共5页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：开玛是计算机辅助即时监测给药系统的简称，它可维持药物效应在预定水平。根据药理效应和同时记录进入体内的药量，开玛可以揭示机体的反应性。22只出血性休克家兔给予0.01％间羟胺3h使血压维持在休克前水平。根据间羟胺药量和血压变化，家兔表现出3种不同类型：下降型、上升型和迟钝型。下降型和上升型动物血压都能维持在预定水平，但间羟胺的剂量却分别表现为逐渐下降或上升，而迟钝型的血压即使以最大速度恒速灌注也不能升到预定值。血乳酸浓度的测定说明间羟胺对每种类型的治疗效果是不同的。开玛系统揭示的失血性休克家兔对间羟胺的个体差异性，这是其它方法难以做到的。The CAAN is the abbreviation of Computer-Assisted Instant Monitoring Drug Administration, which keeps the pharmacotogical effect at preset level. Providing a simultaneous recording Of drug quantity entering the body and its pharmacotogical effect,CAIMA can reveal the individual reactivity to drugs. 22 hemorrhagic shock rabbits were given 0.01% metaraminol (MET)to keep blood pressure (BP) at preshock level for 3 h. According to the changes of MET doses and BP. Profiles, the rabbits exhibited 3 distinct response tynes: descending type, climbing type and sluggish type. The BP in both descending and climbing types reached and kopt at preset level but MET doses gradually decreased or increased respectively. The BP in sluggish type didn't reach the preset level even with the maximum rate infusion. The blood concentration of lactic acid also demonstrated that the theropeutic effects of MET in each type was quite doprent. The effect that CAIMA revealed the individual reactivity to MET in hemorrhagic shock rabbits, is not available by any other methods.

关 键 词：开玛系统 出血性休克 间羟胺 用药反应 个体差异 

分 类 号：R605.971[医药卫生—急诊医学] R452[医药卫生—外科学]