AMI患者血清ALD、CorRIA及其临床意义  

Clinical Significance of Changes of Serum Aldosterone and Corisol Levels in Patients with Acute Myocardial Infarction

作　　者：王金花[1] 季乃军[2] 王成尧[2] 陈东海[2] 

机构地区：[1]浙江省台州市中医院,318000 [2]浙江省丽水市人民医院,323000

出　　处：《放射免疫学杂志》2007年第4期313-315,共3页Journal of Radioimmanology

摘　　要：目的:探讨急性心肌梗死(AMI)患者血清醛固酮(ALD)和皮质醇(Cor)水平的变化及其临床意义。方法:采用放射免疫分析测定了58例急性心肌梗死(AMI)和30例正常对照组的血清ALD和Cor水平,进行对照统计分析。结果:AMI组血清ALD和Cor水平显著高于对照组(193.6±50.1ng/Lvs83.2±34.4ng/L,t=10.81,P<0.01;207.0±80.2nmol/Lvs105.5±49.1nmol/L,t=6.332,P<0.01),且两者成显著正相关(r=0.884,P<0.01)。合并心功能不全组血清ALD和Cor均显著高于无心功能不全组(t=6.141,P<0.01;t=6.134,P<0.01),住院死亡组血清ALD和Cor也显著高于转出院组(t=5.063,P<0.01;t=6.601,P<0.01)。结论:AMI患者血清ALD和Cor水平显著升高,合并心力衰竭组和住院期间死亡组升高更明显。Objective To investigate the changes of serum aldosterone（ALD） and eortisol（Cor） levels in patients with acute myocardial infarction（AMI）. Methods Serum ALD and Cor levels were measured with RIA in 58 patients with AMI and controls. Fiesuits Serum ALD and Cor levels were significantly increased in patients with AMI （ 193.6 ± 50.1 ng/L vs 83.2 ± 34.4ng/L in controis, t=10. 81, P 〈0.01,207.0 ± 80.2nmol/L vs 105.5 ±49. lnmol/L, t =6. 332,P 〈0.01） ,and the serum ALD level was significantly positively correlated with the serum Cor level （r = 0. 884, P 〈 0.01 ）. ALD and Cor levels in patients with heart failure were sitmificantly higher than those in patients without heart failure （ t = 6. 141, P 〈 0.01, t = 6. 134, P 〈 0.01 ）. ALD and Cor levels in patients succumbed were signiticanfly higher than those in patients recovered（ t = 5. 063, P 〈 0.01 ; t = 6. 601, P 〈 0.01 ）. Conclu- sion ALD and Cor were increased in AMI patients, and most markedly in those with heart failure or succumbed.

关 键 词：急性心肌梗死 醛固酮 皮质醇 放射免疫分析 

分 类 号：R542.22[医药卫生—心血管疾病]