老年痴呆患者血浆β-AP RIA的临床意义  

Clinical Significance of Detection of Plasma β-amyloid Protein (β-AP) Levels in Patients with Senile Dementia

作　　者：余斌伟[1] 徐尚敖[1] 陆志峰[1] 王伟华[2] 毛晓华[2] 周朝华 

机构地区：[1]浙江省江山市人民医院检验科,324100 [2]浙江省江山市人民医院内科,324100 [3]浙江省江山市精神病医院,324123

出　　处：《放射免疫学杂志》2007年第4期319-321,共3页Journal of Radioimmanology

摘　　要：目的:探讨血浆β-淀粉样蛋白(β-AP)含量的检测对老年痴呆病的诊断与疗效观察及监视病情发展的临床意义。方法:应用放射免疫分析,测定43例老年性痴呆(AD)患者及58例健康老年人血浆中的β-AP的浓度;分析和观察AD患者β-AP的含量与整体衰退量表(GDS)进程的变量关系和治疗前后β-AP含量的变化。结果:AD组β-AP的含量均明显高于健康对照组(P<0.01)。发现AD患者β-AP的含量水平基本随着GDS程度的加重而增高,但亦有某些晚期病例β-AP的含量不增高或呈下降趋向。脑蛋白水解物(cerebrolysin)治疗后的AD病人β-AP的浓度明显降低(P<0.05)。结论:β-AP的测定可作为AD病诊断的一项生化指标,进行β-AP的动态检测对于了解疾病的过程,观察药物的疗效,判断预后均有重要意义。Objective To explore the value of determination of plasma β - AP leveLs in the diagnosis and monitoring of Alzheimer＇ s disease （AD）. Methods Plasma β - AP levels were weasured with RIA in 43 patients with AD and 58 controls, as well as in 8 AD patients after a course of cerebrolysin treatment. Results The plasma β - AP levels in the AD patients were significance higher than those in controls （P 〈0. 01 ）. The plasma β -AP levels were especially higher in the severe cases, however, the plasma β- AP levels in some late AD patients dropped again, even lower than those in the controls. The plasma β - AP levels in the 8 AD patients decreased significantly after treatment with cerebrolysin. Conclusion The plasma β - AP is a biochemical maker of AD. Dynamic exanmation of plasma β - AP levels is valuable in assessing the progression and prognosis of the disease.

关 键 词：老年性痴呆 Β-淀粉样蛋白 整体衰退量表 放射免疫分析 

分 类 号：R277.791.6[医药卫生—中医学]