血清NSE、CEA、CYFRA21-1联检对肺癌的诊断价值  

Diagnostic Value of Combined Determination of Serum NSE,CEA and CYFRA21-1 Levels in Patients with Lung Cancer

作　　者：丁志祥[1] 秦建萍[1] 杨春秀[1] 金文涛[1] 

机构地区：[1]南京中医药大学附属常州中医院检验科,213003

出　　处：《放射免疫学杂志》2007年第4期360-362,共3页Journal of Radioimmanology

基　　金：江苏省常州市科技计划项目(CS2006220)

摘　　要：目的:探讨联检血清肿瘤标志物神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)对肺癌的诊断价值。方法:采用电化学发光法检测102例肺癌患者和50例良性肺病患者血清NSE、CEA、CYFRA21-1的含量。结果:肺癌患者血清NSE、CEA、CYFRA21-1水平均明显高于良性肺病患者,差异有统计学意义(P<0.01)。三种血清标志物的分布有明显的病理倾向性。NSE在小细胞癌中表达水平较高,其敏感性为59.4%;CEA在腺癌中表达水平较高,其敏感性为61.5%;而CYFRA21-1则在鳞癌中表达水平较高,其敏感性为64.5%。联检可提高检测肺癌的敏感性。结论:三种血清肿瘤标志物对于肺癌的辅助诊断有一定的临床意义,联检NSE、CEA和CYFRA21-1可以提高肺癌的诊断敏感性,为肺癌的早期诊断、病理分型提供可靠的依据。Objective To investigate the diagnostic value of serum NSE, CEA and CYFRA21 - 1 levels determination in patients with lung cancer. Methods Serum levels of NSE, CEA and CYFRA21 - 1 were measured with ECLIA in 102 patients with lung cancer and 50 patients with benign lung diseases. Results The levels of NSE, CEA and CYFRA21 - 1 in serum were much higher in lung cancer group than those in patients with benign lung diseases （ P 〈 0.01 ）. Positive rate of different markers varied with different parthology. The level of serum NSE was highest in SCLC（sensitivity =59.4% ）, CEA was highest in adenocarcinoma（sensitivity =61.5% ）, and CYFRA21 - 1 was highest in squamous（ sensitivity = 64.5% ）. Combined measurement of three tumor markers could improve the all over diagnostic sensitivity in lung cancer. Conclusion Combined measurement of serum NSE, CEA and CYFRA21 - 1 levels can increase diagnostic sensitivity, which is helpful for early diagnosis and predicting pathologic type in patients with lung cancer.

关 键 词：肺癌 神经元特异性烯醇化酶 癌胚抗原 细胞角蛋白19 肿瘤标志物 

分 类 号：R181.3[医药卫生—流行病学]