UCP3基因多态性与DR关系的研究  

The Relationship Between UCP 3 Genetic Polymorphisms and Diabetic Retinopathy in Local Population

作　　者：杨玉芝[1] 李贤厚[1] 冯琨[1] 朱巍[1] 段滨红[1] 王亦薇[1] 王丹[1] 杜馥曼[1] 

机构地区：[1]黑龙江省医院内分泌科,150036

出　　处：《放射免疫学杂志》2007年第4期362-364,共3页Journal of Radioimmanology

基　　金：黑龙江省卫生厅攻关项目(GC04C30801)

摘　　要：目的:探讨解偶联蛋白(UCP)3基因G304A多态性与糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法:201例糖尿病患者(分为伴有DR组45例,不伴有DR的糖尿病患者作为对照组156例),检测所有患者的基因组,用聚合酶链反应(PCR)对UCP3基因进行扩增,记录各组UCP3等位基因及基因型频率并进行比较。结果:UCP3基因G304A多态性和基因频率在各组间无显著性差异(P>0.05)。结论:解偶联蛋白(UCP)3基因G304A多态性与中国人糖尿病视网膜病变无关系。Objective To study the relationship between UCP 3 G304A genetic polymorphism with diabetic retinopathy （DR） in local population. Motthods 201 diabetic patients were of two groups： 45 patients with refinopathy and 156 patients without retinopathy. UCP2 gene was amplified with PCR and genotype frequency was determined. Results The result indicated that there was no significant difference of UCP3 G304A genetic polymorphisms in the two groups. Conclusion UCP3 G304A genetic polymorphisms are unrelated to diabetic retinopathy in local population.

关 键 词：糖尿病 糖尿病肾病 解偶联蛋白-3基因 多态性 

分 类 号：R541.4[医药卫生—心血管疾病]