甲硝唑结肠定位微丸的制备及体外释放度研究  

Studies on Metronidazole Colon-specific Pellets and Its Release in Vitro

作　　者：罗昕[1] 平其能[2] 柯学[2] 佘佐彦[2] 

机构地区：[1]中山大学药学院,广州510080 [2]中国药科大学药剂教研室,南京210009

出　　处：《中国药学杂志》2007年第16期1233-1236,共4页Chinese Pharmaceutical Journal

摘　　要：目的制备甲硝唑结肠定位微丸,以体外释放度为指标,筛选合适的处方。方法采用水性包衣技术,以HPMC和EC为包衣材料制备时控型结肠定位微丸,以EC和Eudragit L30D-55为包衣材料制备pH依赖型结肠定位微丸。结果时控型结肠定位微丸6h释药量在20%左右,pH依赖型结肠定位微丸6h释药量在25%左右。结论体外试验表明,制剂具有较好的结肠定位效果。OBJECTIVE To prepare metronidazole colon-specific pellets, and screen formulations according to the profile of release in vitro. METHODS By using aqueous coating technique, time-dependent controlled colon-specific pellets were prepared with HPMC and EC,and pH-dependent pellets were prepared with EC and Eudragit L30D-55. RESULTS Time-dependent controlled co- lon-specific pellets released about 20% and pH-dependent pellets released about 25% at 6 h. CONCLUSION Test in vitro showed preparations had colon-specific capability.

关 键 词：甲硝唑 结肠定位微丸 流化包衣 体外释放度 

分 类 号：R944[医药卫生—药剂学]