芬太尼静脉镇痛对严重烧伤患者血浆细胞因子的影响  

THE EFFECTS OF INTRAVENOUS ANALGESIA WITH FENTANYL ON CYTOKINE OF PATIENTS WITH SEVERE BURN

作　　者：张晓明 甘建辉[2] 李景武[2] 

机构地区：[1]河北省唐山市工人医院,唐山063000 [2]河北省唐山市人民医院

出　　处：《现代预防医学》2007年第16期3049-3050,共2页Modern Preventive Medicine

基　　金：疼痛治疗对严重烧伤病人细胞因子的影响(06134601A-16)

摘　　要：[目的]探讨严重烧伤患者芬太尼静脉镇痛对血浆细胞因子的影响。[方法]选择20例严重烧伤患者于伤后6h内入院,在积极抗休克的同时,全部患者持续静脉泵入芬太尼10μg/ml+氟哌利多50μg/ml进行镇痛治疗,持续输入量2ml/h。检测镇痛前和镇痛后4、12、24h和48h血浆中白细胞介素6(IL-6)、IL-10和肿瘤坏死因子α(TNF-α)的浓度。[结果]全部患者镇痛开始后IL-6、IL10和TNF-α与镇痛前比较均有明显变化(P﹤0.05),其中IL6和TNF-α镇痛开始后12h和24h与镇痛前比较明显降低(P﹤0.05),而IL10镇痛开始后4、12、24h和48h与镇痛前比较均明显增高(P﹤0.05)。[结论]芬太尼静脉镇痛可以有效地预防或减轻严重烧伤患者的免疫抑制。[Objective] To investigate the effects of intravenous analgesia with Fentanyl on cytokine of patients with severe burn. [Methods] 20 patients with severe burn were hospitalized within 6 hours after injury. While receiving active antishock treatment, all the cases were intravenously pumped with Fentany] 10 mg/L ＋ Droperidol 50 mg/L for analgesia, with the background infusion of 2 ml/h. The levels of IL-6. IL-10 and TNF-ot were determined both before and after analgesia at 4h, 12h, 24h and 48h respectively. [Resultsl After analgesia, the levels of IL-6, IL-10 and TNF-αall changed significantly （P 〈 0.05）. The levels of IL-6 and TNF-α were obviously lower at 12h and 24h after analgesia than those before analgesia （P 〈 0.05）. The level of IL-10 was significantly enhanced at 4h, 12h. 24h and 48h respectively after analgesia （P 〈 0.05）. [Conclusions] Intravenous analgesia with Fentanyl can effectively prevent or relieve the immunosuppression of patients with severe burn.

关 键 词：烧伤 芬太尼镇痛 细胞因子 

分 类 号：R644[医药卫生—外科学]