旋毛虫排泄/分泌(ES)抗原致鼠胸腺淋巴细胞凋亡的研究  

Trichinellla spiralis muscle larve ES antigen-induced apoptosis in mice thymus lymphocytes

作　　者：花丽茹[1] 董晓波[1] 李冬梅[1] 韩周[1] 宋铭忻[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《中国预防兽医学报》2007年第8期615-617,共3页Chinese Journal of Preventive Veterinary Medicine

基　　金：霍英东青年教师基金(91034);中国博士后科学基金(2004035160)

摘　　要：本试验首次以体外培养的小鼠胸腺淋巴细胞为实验对象,加入旋毛虫(Trichinella spiralis)肌幼虫ES抗原做刺激物,通过对鼠胸腺淋巴细胞DNA损伤、凋亡水平的检测,进而证明旋毛虫肌幼虫ES抗原能够诱导鼠胸腺淋巴细胞发生调亡。掌握这种免疫细胞凋亡(apoptosis)发生的过程,对分析免疫应答的特点和调控,以及探索旋毛虫病(Trichinosis)的发病机制和提供防治对策都具有重要意义。In order to study the relationship between apoptosis and Trichinella spiralis infection, mice thymus lymphocytes cul- tured in vitro was induced by T.spiralis muscle larvae ES antigen and the rate of DNA damages and apoptosis caused by the ES antigen were examined. The findings laid foundation for further studies in pathogenesis and prevention of T.spiralis infection.

关 键 词：寄生虫感染 旋毛虫感染 鼠胸腺细胞 细胞凋亡 

分 类 号：S852.4[农业科学—基础兽医学]