社区人群高血压和血管内皮功能指标的现况调查及相关分析  

Study on the correlation between hypertension and the indexes of vascular endothelial function among people living in the community

作　　者：黄海威[1] 谭双全[1] 付贤[1] 彭丹心[2] 刘秀琴[3] 林锐金 吴述恒 黄家星[5] 

机构地区：[1]中山大学附属第一医院神经科,广州510080 [2]中山大学附属第一医院感染管理科,广州510080 [3]中山大学放射免疫检测中心 [4]佛山市顺德区容奇医院 [5]香港中文大学威尔斯亲王医院内科及药物治疗系

出　　处：《中华流行病学杂志》2007年第8期798-801,共4页Chinese Journal of Epidemiology

基　　金：广东省科技计划基金(2004B33801002);广东省自然科学基金(06021358)

摘　　要：目的调查社区人群高血压和血管内皮功能指标的现状,进一步分析高血压的危险因素,探讨高血压患者血管紧张紊Ⅱ、前列环素和一氧化氮水平的变化。方法整群抽取社区汉族成年居民1134人,测量其身高、体重、腰围、臀围和血压,并记录病史资料。用镉还原法检测血清一氧化氮水平,用放射免疫分析法检测血浆血管紧张素Ⅱ和前列环素的浓度。所有数据用SPSS 13.0软件进行统计分析。结果目标人群中高血压患者占44.5%,标准化患病率为15.3%。随着年龄的增加高血压患病率逐渐升高。超重和肥胖是高血压患病的独立危险因素,性别、吸烟史和饮酒史没有进入高血压的logistic回归方程。高血压三组的血管紧张素Ⅱ水平都比正常组低,其中以已控制血压组最低;已控制血压组和已知高血压未控制组的前列环素和一氧化氮水平较正常组升高,差异有统计学意义。而新查出高血压组前列环素和一氧化氮水平升高的差异无统计学意义。结论高血压的患病率呈逐年升高的趋势,控制体重将有利于高血压的预防。推测:患高血压后,人体内肾素-血管紧张素-醛固酮系统的负反馈调节机制依然存在,这一假想可能有助于高血压发病机制的进一步研究。Objective To study the features of hypertension and vessel endothelium functional parameter in people living at the community level as well as the risk factors of hypertension. Differences of angiotensin Ⅱ （Ang Ⅱ ）, prostacyclin （PGI2） and nitric oxide （NO） among normal group and three hypertension groups were also studied. Methods By cluster sampling, 1134 adult Han people were selected from the residential communities. Medical history was documented and measurements of body height, body weight, waist circumference, hip circumference and blood pressure were performed. Serum NO levels were determined by cadmium reduction method while plasma Ang 11 and PGI2 concentration were determined by radioimmunoassay. SPSS 13.0 was used for data analysis. Results The total ratio of hypertension from people living at the community was 44.5 %, with the standardized prevalence of hypertension as 15.3 %. With the increase of age, the prevalence of hypertension also increased. Overweight and obesity seemed to be independent risk factors for hypertension. History of smoking and drinking and gender did not enter the logistic equation for hypertension. The amount of plasma Ang Ⅱ concentration of the three hypertension groups was significantly lower than that in the normal group while the lowest group appeared to from the one that hypertension was under control. The NO and PGI2 levels of the two groups whose hypertension had been known were significantly higher than in the normal group while the difference between the group whose hypertension had not been measured and the normal group was not found. Conclusion The prevalence of hypertension had been increasing. Control of body weight seemed to be a useful way for prevention of hypertension. We assumed that the negative feedback regulation of renin-angiotonin- aldosterone system in hypertension patient still existed which called for the research on the mechanism of hypertension.

关 键 词：高血压 血管紧张素Ⅱ 前列环素 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]