代谢综合征与冠心病的相关性研究  

Relationship between metabolic syndrome and coronary heart disease

作　　者：殷樱[1] 陈庆伟[1] 吴庆[1] 柯大智[1] 李桂琼[1] 邓玮[1] 

机构地区：[1]重庆医科大学附属第二医院老年病科,400010

出　　处：《中华老年医学杂志》2007年第8期572-575,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨代谢综合征（metabolic syndrome,MS）与冠状动脉粥样硬化性心脏病（CHD）发生的关系。方法选择因胸痛临床疑诊CHD住院的患者318例,经冠状动脉造影检查分为：CHD组210例,其中并存MS 102例（CHD-MS组）,单纯CHD组108例；非CHD组108例,其中MS 30例（MS组）,78例未并存MS为对照组。分别检测患者的体质指数（BMI）、血脂、血糖和血压等指标,进行MS与CHD的相关性分析。结果318例患者中,MS发生率为41.5%,其中男、女分别为40.1%（61/152）和42.8%（71/166）。CHD患者的MS发生率高于非CHD患者（分别为48.6%与27.8%,P〈0.01）。CHD-MS组的多支病变、不稳定性病变、需要血运重建分别为29.4%、73.5%和52.9%．均高于单纯CHD组（分别为9.2%、50.0%、25.0%）,均为（P〈0.05）。CHD发生的危险性和冠状动脉病变支数与MS呈正相关（γ分别为0.225,0.361,均为P〈0.01）。结论MS在CHD的发生、发展过程中起到了促进作用,加重了冠状动脉病变的程度,增加了罹患CHD的危险性。Objective To investigate the relationship between metabolic syndrome （MS） and coronary heart disease （CHD）. Methods A total of 318 patients who underwent coronary angiography were recruited in this study, among whom 210 cases were diagnosed as CHD, and subdivided into CHD-MS group （102 cases） and simple CHD group （108 cases）. The patients without CHD belonged to non-CHD group（n= 108）, who were subdivided into MS group （30 cases） and control group （78 cases）. The data of body mass index （BMI）, blood fat, blood uric acid, plasma fibrinogen, blood glucose and blood pressure of each patient were collected, and the anatomy of coronary vessels was analyzed by selective coronary angiography, the relationship between MS and CHD was analyzed. Results The prevalence of MS was significantly higher in CHD group than in non-CHD group （48.6% vs. 27.8%, P〈0.01）. CHD-MS group had a higher incidence of multivessel disease and unstable lesions and more revascularization procedures as compared with simple CHD group （29.40/00 vs. 9.20/00, 73.5% vs. 50.0%, 52.90/00 vs. 25.0%, all P〈0.05）. The incidence of CHD and the number of blocked coronary vessels were positively correlated with MS by Spearman correlation analysis （r=0.225, P〈0.05; r=0.361, P〈0.01）. Logistic regression analysis demonstrated that both the risk of CHD and the number of blocked coronary vessels were positively correlated with MS （P〈0.01）. Conclusions MS can predict the incidence and extent of future CHD.

关 键 词：代谢综合征X 冠状动脉疾病 

分 类 号：R686[医药卫生—骨科学]