氧化苦参碱治疗肾综合征出血热的临床疗效观察  

Observations on clinic curative effect of oxymatrine to cure hemorrhagic fever with renal syndrome(HFRS)

作　　者：于仲青[1] 王岩[2] 曾庆友 陈立艳[2] 王建勋 杨建勋 李淑华 杨宝山[2] 

机构地区：[1]黑龙江省医院感染内科,哈尔滨150036 [2]哈尔滨医科大学第一临床医学院感染病科 [3]黑龙江省九三农管局中心医院感染科 [4]讷河市第一人民医院感染科(李淑华)

出　　处：《中华医学杂志》2007年第30期2126-2128,共3页National Medical Journal of China

摘　　要：目的观察氧化苦参碱对于肾综合征出血热的治疗效果。方法将418例肾综合征出血热患者随机分为治疗组和对照组,治疗组应用氧化苦参碱静脉点滴,每日1次,每次600 mg,疗程为7 d,对照组应用传统的平衡盐疗法。观察两组患者的病情转归及并发症发生情况,动态检测患者血清中血清尿调蛋白(THP)和β_2微球蛋白(β_2M)的水平,同时观察血清白细胞介素15(IL-15)及可溶性细胞间黏附分子(slCAM-1)水平变化。结果氧化苦参碱治疗组患者病程缩短、预后改善,血清 THP 和β_2M 的水平均明显低于对照组,且治疗后血清 IL-15及 sICAM-1水平与对照组相比差异也有统计学意义。结论氧化苦参碱治疗肾综合征出血热疗效确切,值得临床进一步推广使用。Objective To observe the curative effect of oxymatrine to cure hemorrhagic fever with renal syndrome. Methods Randomly divide 418 patients suffering from hemorrhagic fever with renal syndrome into a treatment group and a control group, use oxymatrine to give an intravenous drip to the patients in the treatment group, one time a day, each time 600 mg, lasting for 7 days as one period of treatment and meanwhile take a traditional equilibrium salt treatment for the patients in the control group. Observe the change of the illness in both groups and occurrence of complications, dynamically test the magnitude of serum urination-regulated protein （THP） and β2 microglobulin （β2M） of the patients, in the meantime observe the change in magnitude of serum white blood cell medium 15 （IL-15） and soluble intercellular adhesion molecules （sICAM-1）. Results Shorten the course of the disease of the patients in the oxymatrine treatment group, make an improvement after the recovery and obviously reduce the magnitude of serum urination-regulated protein （THP） and β2 microglobulin and show a striking difference in magnitude of serum IL-15 and slCAM-1 after the treatment compared with that of the patients in the control group. Conclusion Oxymatrine has a certainly true curative effect to hemorrhagic fever with renal syndrome and worth of furthering its widespread use in clinics.

关 键 词：肾综合征性出血热 氧化苦参碱 白细胞介素15 细胞黏着分子 

分 类 号：R512.8[医药卫生—内科学]