新疆哈萨克族和维吾尔族及塔吉克族人群中谷胱甘肽转硫酶M1基因多态性分布  

Glutathione-S-transferase M1 polymorphisms among three Chinese minorities:Kazakh,Uygur and Tajik

作　　者：卢晓梅[1] 杨婷[2] 徐淑永[2] 温浩[1] 王星[1] 任智慧[1] 吕国栋[1] 刘涛[1] 王嵬[3] 

机构地区：[1]新疆医科大学第一附属医院医学研究中心实验室,乌鲁木齐830054 [2]新疆医科大学基础医学院 [3]中国科学院研究生院生物系

出　　处：《中华检验医学杂志》2007年第8期903-905,共3页Chinese Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区高技术研究发展计划基金资助课题(XJKJT200511113);乌鲁木齐市科学技术厅基金资助课题(Y05331002);新疆维吾尔自治区高校科研计划青年教师科研基金资助课题(XJ EDV 2004S14)

摘　　要：目的探讨谷胱甘肽转硫酶 M1(Glutathione-S-Transferase M1,GSTM1)基因在新疆哈萨克、维吾尔、塔吉克族人群中基因多态性的分布。方法用 PCR 与电泳技术分析1121名健康人群(男442名,女679名;其中哈萨克族654名、维吾尔族412名和塔吉克族55名)中 GSTM1基因的多态性分布状况。结果 GSTM1基因在维吾尔、塔吉克和哈萨克族中的缺失率分别为62.6%、50.9%和47.4%,其中,维吾尔族中GSTMl基因缺失型(GSTMl null)明显高于哈萨克族(OR:1.859,CI 为1.445～2.391,x^2=23.71,P=0.000),而维吾尔族与塔吉克族之间、哈萨克族与塔吉克族之间GSTM1 null 基因型的分布差异无统计学意义。结论 GSTM1 null 基因型在维吾尔族和哈萨克族人群中分布频率明显不同,提示 GSTM1基因在新疆哈萨克族、维吾尔族人群中的分布存在多态性。Objective To investigate the polymorphisms of Glutathione-S-transferase M1 （ GSTM1 ） in three Chinese minorities, Kazakh, Uygur and Tajik. Methods A total of 1 121 health blood samples （including 442 males and 679 females） were obtained from Xinjiang, China（ including 654 Kazakh, 412 Uygur and 55 Tajik）. GSTM1 polymorphisms were analyzed by a combined approach of Polymerase-Chain- Reaction （ PCR ） and electrophoresis techniques. Results GSTM1 null genotype was found in 62. 6% Uygur, 50.9% Tajik and 47.4% Kazakh ethnic. A significantly higher frequency of GSTM1 null genotype in Uygur ethnic was observed compared with Kazakh （ OR： 1. 859, CI： 1. 445～2. 391 ,X^2 = 23.71, P = 0. 000）. In addition, there were no statistically difference on GSTM1 null genotype between the Uygur and Tajik, as well as between the Kazakh and Tajik. Condusiom The frequency of GSTM1 null genotype is significantly different between Uygur and Kazakh ethnics, suggesting that the GSTM1 polymorphism displayed between Kazakh and Uygur ethnic.

关 键 词：谷胱甘肽转移酶 基因多态性 维吾尔族 塔吉克族 

分 类 号：R450[医药卫生—治疗学]