阿托伐他汀对中国高血压人群颈动脉内膜-中层厚度的影响  

Effect of atorvastatin on carotid intima-medial of thickness of primary hypertension patients of Han nationality in China

作　　者：吴静 吴钢 王梅平[1] 刘东琳[1] 胡志坚[3] 许国英 

机构地区：[1]福建省老年医院神经内科 [2]福建省医科大学附属第一医院神经内科,350005 [3]福建医科大学公共卫生学院流行病与卫生统计教研室

出　　处：《中华医学杂志》2007年第31期2215-2217,共3页National Medical Journal of China

摘　　要：目的观察10 mg 或20 mg 阿托伐他汀+长效降压药治疗对颈动脉内膜-中层厚度(IMT)的作用。方法 151例轻度高血压患者随机分为3组,50例用10 mg 阿托伐他汀+氨氯地平+贝那普利治疗,61例用20 mg 阿托伐他汀+氨氯地平+贝那普利治疗,对照组45例采用氨氯地平+贝那普利治疗;观察治疗前、第3、6、9、12个月 IMT、血管舒张功能、低密度脂蛋白胆固醇(LDL-C)等指标变化。结果 10 mg 或20 mg 阿托伐他汀组与对照组比较结果:(1)颈动脉 IMT 减少(P<0.01);(2)血管舒张功能改善(P<0.01);(3)10 mg 阿托伐他汀组 LDL-C 下降30%,20 mg 组 LDL-C下降40.48%(P<0.01)。结论 10或20 mg 阿托伐他汀能够延缓高血压患者的动脉粥样硬化的发展;改善血管内皮功能;达到强化降脂效果。Objectives To investigate the efficacy of 10 mg or 20 mg atorvastatin ＋ long acting antihypertensive in carotid imtima-medialthickness （ IMT）. Methods 151 patients of Han nationality in South China with mild hypertensive were randomly divided into 3 groups ：atorvastation 10 mg group （ n =50） recevie 10 mg atorvastation and amlodipine ＋ benazepril ; atorvastation 20 mg group （ n = 61 ） receive 20 mg atorvastation and amledipine ＋ benazepril ; the control group （n = 40） recevie amlodipine ＋ benazepril. The patients were detected IMT, vascular function, lipids and inflammatory factor in pretherapy and every 3 months. Results atorvastatin 10 mg or 20 mg groups have significantly change contrast to coutrol group ： （ 1 ） IMT was decreased （P〈0.01）. （2）△dia-P% and △dia-N% were increased（P〈0.01）. （3）LDL-C level was decreased by 30% in a atorvastatin 10 mg group and 40. 48% in 20 mg group respectively （P 〈0. 01 ）. Conclusion Atorvastatin delays the development of artherosclerosis in hypertensive patients, improves endothelial function, and strengthens the effect of lipid-lowering.

关 键 词：脂类和降血脂药 内皮 血管 低密度脂蛋白胆固醇 

分 类 号：R544.1[医药卫生—心血管疾病]