荭草苷对缺血缺氧心肌的保护作用  

Protective effects of orientin on myocardial ischemia and hypoxia in animal models

作　　者：付晓春[1] 王希[1] 郑辉[1] 马丽萍[1] 

机构地区：[1]广东化工制药职业技术学院/广东省中药研究所,广东广州510520

出　　处：《南方医科大学学报》2007年第8期1173-1175,共3页Journal of Southern Medical University

基　　金：广东省科技厅科技攻关项目(2005B30101013)~~

摘　　要：目的研究荭草苷对缺血缺氧心肌的保护作用。方法采用小鼠常压耐缺氧实验、夹闭气管小鼠心电消失时间、豚鼠离体心脏的冠脉流量、花生四烯酸诱导的家兔血小板聚集和垂体后叶素所致大鼠心肌缺血模型,观察荭草苷对缺血缺氧心肌的保护作用。结果荭草苷(1,2,4mg/kg)均能显著延长小鼠常压耐缺氧条件下的存活时间,延长夹闭气管小鼠心电消失时间,荭草苷(3,10,30μmol/L)明显抑制花生四烯酸诱导的家兔血小板聚集并能增加豚鼠离体心脏的冠脉流量。荭草苷(0.75,1.5,3.0mg/kg)能拮抗垂体后叶素引起的心电图变化。结论荭草苷对缺血缺氧心肌具有明显保护作用,其效应与剂量呈相关性。Objective To study the protective effects oforientin against myocardial ischemia and hypoxia in rats. Methods The protective effect of orientin against myocardial ischemia and hypoxia was observed in mice by recording their survival time under closed normobaric hypoxia and time of cardiac electric disappearance due to trachea clamping, in rabbits by evaluating arachidonic acid （AA）-induced blood platelet aggregation, in guinea pigs by measuring the coronal flow in the isolated heart and in SD rats with myocardial ischemia induced by pituitrin injection. Results Orientin （1, 2, 4 mg/kg） significantly prolonged the survival time of mice under closed normobaric hypoxia and the gasping duration induced by decapitation. Orientin at concentrations of 3, 10, and 30 μmol/L also inhibited AA-induced blood platelet aggregation in rabbits and increased coronal flow in the isolated heart of guinea pigs. At 0.75, 1.5, and 3.0 mg/kg, orientin significantly antagonized pituitrin-induced ECG changes. Conclusion Orientin may offer protection against myocardial ischemia and hypoxia in animal models in dose-dependent fashions.

关 键 词：荭草苷 心肌缺氧 心肌缺血 血小板聚集 垂体后叶素 

分 类 号：R285[医药卫生—中药学]