康复新结肠靶向胶囊的体内外评价  

In vivo/in vitro evaluation of Kangfuxin colon targeting capsules

作　　者：邱雪兰[1] 杨明[2] 谢兴亮[2] 赖娟[2] 陈斯玮[2] 

机构地区：[1]四川大学华西药学院,四川成都611730 [2]成都中医药大学药学院,四川成都610041

出　　处：《中国中药杂志》2007年第16期1644-1647,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30371780)

摘　　要：目的:对康复新pH依赖和酶依赖靶向胶囊进行体内外药剂学实验,评价其结肠定位释放效果。方法:采用溶出度测定中的桨法对制剂进行体外评价,X射线造影法观察其体内运转情况。结果:pH依赖结肠靶向制剂在人工结肠液中2 h后,药物基本释放完全,达到结肠定位释放;酶依赖结肠靶向制剂在人工结肠中加入酶后,药物释放迅速,基本达到结肠定位释药;pH依赖和酶依赖靶向胶囊的体内转运时间都存在较大个体差异,受试药物的崩解时间在不同个体间较稳定,集中在2.0～3.5 h。结论:2种原理的康复新结肠靶向胶囊均基本实现在结肠定位释放药物。Objective： To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro. Method： The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo. Result： After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loe-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0 - 3. 5 hours. Conclusion： Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.

关 键 词：康复新 结肠靶向 溶出度 X射线造影 

分 类 号：R285[医药卫生—中药学]