芳香型二丁基锡双羧酸酯的合成、表征及抗癌活性研究  

Synthesis,Characterization of Aromatic Di-nbutyltin Dicarboxylates and Anticancer Activities

作　　者：杨菘[1] 邓小强[1] 陈四海[1] 龙伯华[1] 吴运东[1] 向建南[1] 

机构地区：[1]湖南大学化学化工学院

出　　处：《湖南大学学报（自然科学版）》2007年第8期48-53,共6页Journal of Hunan University:Natural Sciences

基　　金：国家自然科学基金资助项目(20472018);湖南省自然科学基金资助项目(03JJY3016)

摘　　要：用二正丁基氧化锡和取代芳香单羧酸以1∶2摩尔比反应,合成了10个芳香型二正丁基锡双羧酸酯n-Bu2Sn(OOCAr)2(3a^3j).利用1H NMR,119Sn NMR和IR等对这些化合物进行了表征.并用X-射线单晶衍射测定了其中化合物3b和3e的晶体结构.3b和3e晶体中锡原子配位数均为6,形成了严重扭的曲八面体几何构型.3b和3e均存在分子内及分子间氢键作用,3b中氢键作用较弱,在生物体系中比3e更易释放出游离态R2Sn2+,易与癌细胞的DNA结合,具有更好的抗癌生物活性.A series of di-nbutyltin diearboxylates n-BuaSn（OOCAr）2 （3a-3j） were synthesized by the reaction of di-nbutyltin oxide with the corresponding aromatic earboxylie acids in 1 ： 2 molar ratio. These compounds were characterized by 1HNMR, 119SnNMR and IR. Compounds 3b and 3e were determined by X-ray single crystal diffraction. In the the crystals of 3b and 3e, each tin atom is six-coordinated in a distorted oetahedron geometry structure. The structures of 3b and 3e exist in their crystals by intermoleeular and intramoleeular hydrogen bonds. 3b presented better antieaneer activity because the hydrogen bonds in 3b are longer and weaker, so that the species RRSn^2＋ of 3b in bio-system is released more easily to combine with DNA of cancer cells.

关 键 词：二正丁基氧化锡 合成 晶体结构 抗癌活性 

分 类 号：O621[理学—有机化学]