3-N-苄氧羰基-β-氨基丁酸糖酯的合成及生物活性  

Synthesis and Bioactivity of 3-N-Benzyloxycarbonyl-β-aminobutyric Saccharide Carboxylate

作　　者：臧洪俊[1] 李正名[2] 范志金[2] 刘秀峰[2] 王素华[2] 

机构地区：[1]天津工业大学材料科学与化学工程学院改性与功能纤维天津市重点实验室,天津300160 [2]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《高等学校化学学报》2007年第8期1512-1515,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点项目(批准号:20432010);国家自然科学基金(批准号:30270883)资助

摘　　要：将两类具有重要生物活性的结构单元β-氨基丁酸和糖分子结合在一个分子内,设计合成了8个新糖酯化合物.经元素分析和1H NMR确认了其结构.初步生物活性测定结果表明,该类化合物具有一定的诱导活性,且一些化合物的诱导活性比水杨酸的好.The plant activators such as D,L-β-aminobutyric acids can induce systemically acquired resiatance in the treated plants against the pathogen infection. Saccharide carboxylate compounds are known for their physiological and pharmaceutical importance. In order to investigate the synergic effect of the glucose and β-aminobutyric acid , eight new glycosyl esters of β-aminobutyric acid were synthesized with the reaction of 3-N-benzyloxycarbonyl-β-aminobutyric acid with acetylated glycosyl bromide or di-O-isopropyllidene-glucose. The structures were confirmed via elemental analysis and ^1H NMR. Bioassay results indicate that several compounds show a better induced activity against pathogen infection than salicylic acid.

关 键 词：D L-β-氨基丁酸 糖酯 植物诱导抗性 生物活性 

分 类 号：O625[理学—有机化学]