β-磷酸三钙／α-半水硫酸钙复合人工骨修复骨缺损的影像学评价  

Radiographic evaluation of the bone graft of β-calcium tricalcium phosphate / α-caleium sulphatehemihydrate

作　　者：毛克亚[1] 王岩[1] 侯喜君[1] 梁茂华[1] 王继芳[1] 陈大福[2] 李江涛[3] 

机构地区：[1]解放军总医院骨科,北京100853 [2]北京市创伤骨科研究所 [3]中国科学院理化技术研究所

出　　处：《中华创伤骨科杂志》2007年第8期714-716,共3页Chinese Journal of Orthopaedic Trauma

基　　金：军队“十一五”科研课题（2005jd0003）

摘　　要：目的通过影像学探讨β-磷酸三钙／α-半水硫酸钙（β-TCP／α-CSH）复合人工骨的体内降解和成骨性能。方法制备兔股骨髁10mm×5mm包容性骨缺损模型，将自行研制的β-TCP／α-CSH复合人工骨颗粒制备成与缺损大小相同的圆柱状试件并植入缺损内，于术后4、8、12周采用X线、钼靶照相等方法观察骨缺损修复情况。结果β-TCP／α-CSH复合人工骨植入体内后逐渐降解，被自体骨爬行替代，12周时骨缺损部位大部分被新生骨取代，X线密度与周围正常骨组织接近。结论β-TCP／α-CSH复合人工骨修复包容性骨缺损具有优良的降解和成骨性能。Objective To investigate the in vivo degeneration and osteogenous activity of the bone graft of β-calcium tricalcium phosphate / a-calcium sulphate hemihydrate （β-TCP /α-CSH） by radiography, Methods The models of column bone defects （ 10 mm × 5 mm） were made in the femoral condyles in rabbits. The bone grafts composed of β-TCP /α-CSH with the same size were made and implanted into the bone defects. The degeneration and new bone formation of the grafts were observed by X-ray and molybdenum target films in postoperative 4, 8 and 12 weeks. Results The degeneration of bone grafts and creeping substitution by new bone started after implantation. Most of the bone grafts were replaced by new bone at 12 weeks, with the X-ray density close to that of the normal bone nearby. Conclusion The degeneration and osteogenous activity of β-TCP /α-CSH bone grafts are perfect in the models of contained bone defects.

关 键 词：磷酸钙类 硫酸钙 骨重建 影像学 

分 类 号：R686[医药卫生—骨科学]