杭州市莱姆病血清流行病学调查  

Investigation on the Seroepidemiology of Lyme Disease in Hangzhou

作　　者：崔威武[1] 邓晶[1] 施世锋[1] 黄仁杰[1] 许珂[1] 黄诚孝[1] 干伟群[2] 徐校平[3] 许向军[4] 孙昼[1] 王国祥[1] 万康林[5] 

机构地区：[1]杭州市疾病预防控制中心,浙江310006 [2]杭州市余杭区疾病预防控制中心 [3]建德市疾病预防控制中心 [4]临安市疾病预防控制中心 [5]中国疾病预防控制中心传染病预防控制所

出　　处：《中国预防医学杂志》2007年第4期382-386,共5页Chinese Preventive Medicine

摘　　要：目的了解杭州市莱姆病的感染状况、流行病学特征,分析影响感染率的因素,提出杭州市莱姆病防治对策。方法选择余杭区、临安市和建德市等三地部分林场的职工和山村的居民进行血清流行病学调查。用间接免疫荧光方法（IFA）检测人血清抗莱姆病螺旋体抗体（IgG）,对莱姆病抗体检测阳性血清进行钩端螺旋体和梅毒螺旋体交叉试验,以排除钩体和梅毒螺旋体的交叉感染。结果932份进行莱姆病抗体检测以及梅毒和钩体鉴别试验的血清标本中,判定为莱姆病感染的为111份,感染率为11.91%。男性的莱姆病感染率略高于女性,但经统计学检验,差异无统计学意义（P〉0.05）。除10-岁组和70-岁组两个年龄组的感染率略低外,其余各年龄组间的感染率较为接近,且经统计学检验,各年龄组之间的感染率差异无统计学意义（P〉0.05）。杭州市不同地区间的莱姆病感染率存在差异,经检验差异有统计学意义（P〈0.05）,余杭区的感染率最高,而建德市的感染率最低。山村居民的莱姆病感染率略高于林场职工,但经统计学检验,两者间的差异无统计学意义（P〉0.05）。结论杭州市林场职工和山村居民中普遍存在莱姆病的感染,且感染率较高。人群对莱姆病普遍易感,不论年龄、性别、林场职工或山村居民,只要经常有接触传播媒介的机会,不做好防护而被蜱叮咬,就有可能被感染。提示在杭州市的山区和林场开展莱姆病的防治工作是非常有必要的。Objective To investigate the Lyme Borreliosis infection status of population and epidemiological characteristic in Hangzhou city so as to put forward the preventive measures. Methods Seroepidemiologic investigations were carried out in mountain residents and forestry workers from Yuhang district, Lin＇ an city and Jiande city. All serum samples were detected by indirect immunofluorescent assay test （IFAT） for antibodies （IgG） against Borrelia bugdorferi.Positive sanlples were detected furthermore to distinguish syphilis and leptospirosis. Results Total 932 persons were investigated, 111 persons were determined to be infected with Borrelia bugdofferi and the rate of infection was 11.91% .Infection rate of male was a little higher titan that of female, but there was no significant difference （ P 〉 0.05） .Infection rates showed no significant difference anaong age groups （ P 〉 0.05） .There were significant differences of infection rates among the areas in Hangzhou （P 〈 0.05）, with the lfighest rate in Yuhang district and the lowest rate in Jiande city. The infection rate in mountain residents was a little higber than that of forestry workers, but the difference wasn＇ t significant （ P 〉 0.05）. Conclusion The infection rates of lyme borreliosis were high in mountain residents and forestry workers in Hangzhou. Hunmn, no matter age, sex and occupation, is generally liable to be infected by Borrelia burgdorferi, as long as he is bitten by the tick.It suggests that prevention and control of lyme disease in the people from forestland and mountains in Hangzhou is necessary.

关 键 词：莱姆病 血清流行病学 间接免疫荧光试验 

分 类 号：R181.3[医药卫生—流行病学] R514[医药卫生—公共卫生与预防医学]