血管性认知损害与血浆同型半胱氨酸的关系及临床意义  

Research about the relationship between homocysteine and vascular cognitive impairment

作　　者：金晓睛[1] 章军建[1] 

机构地区：[1]武汉大学中南医院神经内科,湖北武汉430071

出　　处：《中国行为医学科学》2007年第2期109-110,共2页Chinese Journal of Behavioral Medical Science

基　　金：基金项目：国家自然科技基金资助项目（30270483）

摘　　要：目的探讨血管性认知损害（VCI）与血浆同型半胱氨酸（HCY）的关系及意义。方法运用简易智能状态量表（MMSE）和画钟试验（CDT）测定认知功能。用酶免疫分析法（EIA）测定血浆同型半胱氨酸水平。健康对照组50名，非痴呆血管性认知功能损害（VCIND）组53名，血管性痴呆（VaD）组52名。结果VaD组患者的血浆HCY浓度[（27．64±6．42）μmol／L]浓度高于VCIND组，VCIND组患者HCY浓度[（18．01±5．23）μmol／L]高于健康对照组HCY浓度[（7.24±3.20）μmol／L]，均差异具有显著性。VCI患者MMSE评分与血浆HCY浓度无明显相关（r=-0．23；P〉0．05），但在HCY〉14．1μmol／L时其与MMSE的评分呈负相关（r=-0．39，P=0．006），且高HCY与注意力和执行功能有明显相关（P〈0．05）。结论HCY可能是血管性认知功能损害的重要生化指标。Objective Explore the relationship between homocysteine （HCY） and vascular cognitive im- pairment （VCI）. Methods （1）Cognitive evaluation： mini-mental state examination （MMSE） and purdue peg- board test were used to evaluate the patients cognitive impairment, （2）The HCY concentration in serum was determi- nated by ELISA . （3）Grouping：the controlled group with 50 cases,the vascular cognitive impairment with no demen- tia（VCIND） group with 53 cases,the vascular dementia（VaD） group with 52 cases. Results The HCY concen- tration of VaD group [ （ 27.64±6.42 ）μmol/L ] was higher than that of the VCIND group [ （ 18.01±5.23 ）μmol/L] ;and the VCIND group was higher than the controlled group [ （7.24±3.20） μmol/L ], with significant difference（ P 〈 0.05） . MMSE score in all group hade no remarkable relationship with the HCY concentration （ r = -0.23; P〉0.05） ;but it was negatively related to MMSE score when the concentration of the HCY was higher than 14.1 μmol/L（ r = -0.39, P = 0. 006 ）. High HCY levels were not related to the ability of memory and lan- guage,but related to the ability of attention and execution （ P 〈 0.05 ）. Conclusion HCY might be act as the ob- servational marker of VCI in biochemistry.

关 键 词：血管性认知损害 同型半胱氨酸 简易智能状态量表 

分 类 号：R587.1[医药卫生—内分泌]