原发性高血压与内皮素升高关系的研究  

Study on Relationship between Primary Hypertension and Rise in Endothelin Level

作　　者：郭学青[1] 张梦翔 高飞[1] 高云颂[1] 李春英[3] 

机构地区：[1]北京军区总医院263临床部检验科,北京101149 [2]解放军464医院感染控制科,天津300026 [3]北京友谊医院生化实验科,北京100005

出　　处：《华北国防医药》2007年第4期9-10,共2页Medical Journal of Beijing Military Region

摘　　要：目的:研究原发性高血压患者血内皮素浓度的变化,探讨高血压与内皮素升高的关系。方法:用放射免疫法测定40例原发性高血压血内皮素含量,并与40例健康人(对照组)进行对照分析。结果:高血压组内皮素升高,与对照组比较差异具有非常显著性意义(P<0.001),并与血压升高程度呈正相关,高血压组Ⅱ、Ⅲ级与Ⅰ级比较差异具有非常显著性的意义(P<0.01),Ⅲ级与Ⅱ级比较差异具有非常显著性的意义(P<0.01)。原发性高血压并发左心室肥厚(LVH)、心力衰竭组与单纯高血压组内皮素含量比较具有非常显著性的意义(P<0.01,P<0.001);并发心力衰竭组与并发LVH组内皮素含量比较差异具有非常显著性的意义(P<0.01)。结论:内皮素是高血压病理发展过程中的重要参与因素,可作为反映高血压病变程度和动态变化的一项指标,有一定的参考价值。Objective：To study the variation of blood endothelin concentration among essential hypertension patients and discuss the relation- ship between hypertension and the rise in endothelin level. Methods：The blood endothelin level of 40 cases of hypertension patients with ridio immuno assay was measured and comparison analysis against 40 cases of healthy people was conducted. Results： Hypertension patients had higher level of endothelin,with direct proportion to the degree of rise in blood pressure（ P 〈 0. 001 ）. There was an obvious difference between Group 11 ,Ⅲ and I （P 〈 0.01 ） and between Group llI and II （ P 〈 0.01 ） but higher in the case of supervening left ventricular hypertrophy or heart failure （ P 〈 0.01 ,P 〈 0. 001 ）. When compared with the control group the difference was significant betwwen the endothelin level of the heart failure group and the LVH group（P 〈0.01 ）. Conclusion：Endothelin is an important influencing factor of hypertension physiologic and pathologic change process. It can be an indicator of reflecting hypertension pathological process degree and dynamic changes and therefore is a valuable reference.

关 键 词：高血压 原发性 内皮素 左心室肥厚 心力衰竭 充血性 

分 类 号：R544.1[医药卫生—心血管疾病]