BPI-1095对人结肠癌HCT-8细胞增殖及细胞周期的影响  

Effect of NO-ASA on Proliferation and the Cell Cycle in Colon Cancer Cells

作　　者：张魏丽[1] 刘志坤[2] 王印祥 王俊明[1] 

机构地区：[1]河北医科大学公共卫生学院,石家庄050017 [2]河北医科大学第四医院 [3]北京贝达新药研发中心

出　　处：《肿瘤防治研究》2007年第8期579-581,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨NO-ASA体外对结肠癌细胞增殖、细胞周期的影响。方法采用MTT法检测NO-ASA对体外培养的结肠癌细胞的生长抑制作用;用流式细胞仪检测细胞周期分布。结果NO-ASA对结肠癌细胞增殖有明显的抑制作用,呈量效和时效依赖关系;对细胞周期也有明显影响,表现为S期细胞比例和G2/M期细胞比例下降,G1期细胞比例升高。结论体外NO-ASA对结肠癌细胞的增殖有明显抑制作用,对细胞周期也有明显影响。Objective To investigate the effect of NO-ASA on cell proliferation and cell cycle of colon cancer cells. Methods Using MTT method, flow cytometry （FCM）, his effect of BPI-1095 on the HCT-8 of proliferation and cell cycle were studied. Resdts The growth of HCT-8 was inhibited by BPI-1095. The inhibition rate of BPI-1095 on HCT-8 cell proliferation increased as incubation time and BPI-1095 concentration increasing; the cell ratios of S and G2 phase decreased, whereas the cell ratio of G1 phase increased with a dose-dependent manner. Conclusion BPI-1095 inhibited the growth of colon cancer cells and changed the phase of cell cycle.

关 键 词：BPI-1095 结肠癌 细胞抑制 细胞周期 

分 类 号：R446.19[医药卫生—诊断学]