不同抗凝强度华法林对非瓣膜病房颤患者血栓栓塞的预防作用  

Antithrombotic therapy in nonvalvular atrial fibrillation: aspirin and different anticoagulate intensity of warfarin

作　　者：高悦顺[1] 程晓静[1] 张红[1] 付蓉[1] 郭公慧[1] 吴昭德[1] 

机构地区：[1]日照市人民医院,山东日照276826

出　　处：《山东医药》2007年第22期15-16,共2页Shandong Medical Journal

摘　　要：目的观察阿司匹林和不同抗凝强度的华法林对非瓣膜病性房颤患者血栓栓塞并发症的预防效果和安全性。方法将确诊的非瓣膜病房颤患者135例,随机分为阿司匹林组、低强度华法林抗凝组和中强度华法林抗凝组,观察三组栓塞、出血和上腹部不适的发生率。结果低、中强度华法林抗凝组栓塞及上腹部不适的发生率明显低于阿司匹林组(P<0.05);不同强度华法林抗凝组血栓栓塞率比较差异无统计学意义(P>0.05);低强度华法林抗凝组轻微出血发生率明显低于中强度华法林抗凝组(P<0.05);三组均无严重出血发生。结论低强度华法林抗凝能降低非瓣膜病房颤血栓栓塞发生率,出血发生率低,安全性好。[ Objective ] To observe the prophylactic effect and safety of aspirin and different anticoagulate intensity of warfarin on the prevention of thromboembolism in patients with nonvalvular atrial fibrillation. [ Method] 135 patients with nonvalvular atrial fibrillation were randomly divided into three groups. The first group was aspirin group, the seeond group was low intensity warfarin,the third group was middle intensity warfarin, the three groups reeeived aspirin or warfarin. The ineidenee of the side-effeets sueh as thrombo-embolism, hemorrhagie and midsection-diseomfort were eompared. [ Result ] The thrombo-embolism events in aspirin group was higher than that in two warfarin groups （ P 〈 0. 05 ）. The thrombo- embolism events in two warfarin groups were no statistieally signifieanee（ P 〉 0. 05 ）. The minor bleeding events in middle intensity warfarin group was higher than that in low intensity warfarin group （ P 〈 0. 05 ）. There was no serious bleeding in the three groups. [ Conclusion] Low intensity warfarin ean safely and remarkably reduee the ineidenee of thrombo-embolism in patients with non-valvular atrial fibrillation.

关 键 词：非瓣膜病 心房颤动 栓塞 华法林 阿司匹林 

分 类 号：R541.7[医药卫生—心血管疾病]