铅影响学习记忆的机制  

Mechnism of Lead affecting Learning and Memory

作　　者：杨绍杰[1] 孟金萍[1] 屈祎[1] 刘云波[1] 

机构地区：[1]中国医学科学院中国协和医科大学实验动物研究所环境营养室,北京100021

出　　处：《医学综述》2007年第16期1206-1208,共3页Medical Recapitulate

基　　金：国家重点基础研究发展规划973项目(2002CB512901)

摘　　要：铅是最古老的毒物之一。在现今生活中,由于铅的广泛应用使得铅的污染也广泛存在,虽然采取了一些措施来减少铅的影响,但是铅仍然对人体健康造成了很大伤害。铅具有很强的神经毒性,主要表现为铅对未成熟个体学习记忆的损害,使未成年人发生学习记忆功能障碍。本文综述了近几年来铅影响学习记忆的神经分子生物学机制研究进展。Lead （Pb^2 ＋ ） is one of the oldest poison, of which the pollution has wide existance resulting from its widely application in our modem life. Although many measurements had been taken to relieve its influence, lead also did great harmful to human health., lead has high neurotoxicity, of which the manifestafion lies in learning and memery dysfunction of minor resulting from its damage to their learning and memory. This article reviews progresses of lead about its influence on learning and memory from nervous mechanism in molecular biology.

关 键 词：铅 学习记忆 铅毒性 神经毒性 

分 类 号：R995[医药卫生—毒理学]