自体脾移植及食管横断吻合术治疗肝硬化门脉高压症的远期疗效  

The long-term prognosis of spleen autotransplantation combined with lower esophagus transection in the treatment of hepatic cirrhosis complicated with portal hypertension

作　　者：霍景山[1] 陈积圣[2] 吴卓[2] 陈汝福[2] 

机构地区：[1]广东省佛山市中医院,广东佛山528000 [2]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《中国医药导报》2007年第08X期145-146,共2页China Medical Herald

基　　金：广东省佛山市卫生局科研项目(2007100)

摘　　要：目的:探讨腹膜后自体脾移植联合食管横断术治疗肝硬化门脉高压症(PHT)的远期疗效。方法:186例肝硬化门静脉高压症患者,行自体脾移植联合食管横断术治疗。观察其术后远期(2.3～25.2年)一般状况、并发症。测定血清Tuftsin水平、IgM水平、血常规、肝纤维化指标及肝功能的变化,用99mTc及3DDECMRA行脾扫描了解移植脾成活及其侧枝血管的建立。结果:术后一般状况良好,远期并发症无明显增加。全血细胞减少均得到完全纠正,肝功能及肝纤维化指标正常;血清Tuftsin及IgM水平,与术前水平无明显差异。结论:自体脾移植及食管横断吻合术,可作为门静脉高压症常规治疗的选择。Objective：To study the long-term prognosis of spleen autotransplantation in retroperitoneum combined with lower esophagus transection in the treatment for hepatic cirrhosis induced portal hypertension. Methods： 106 cases of portal hypertension were treated by pleen autotransplantation in retroperitoneum combined with lower esophagus transection. The general condition.spleen scanning （by ^99mTc and 3D DEC MRA）.blood routine, liver function.index of liver fibrosis, serum Tuftsin and IgM levels were observed and compared with those before operation. Results：After operation, the patients＇ general condition was well. Long-term complications had no increase. Blood routine and liver function became normal. Serum Tuftsin, index of liver fibrosis and IgM levels had no change. Retroperitoneal transplanted spleen had extensive collateral circulation. Conclusion：Spleen autotransplantation combined with lower esophagus transection in the treatment of hepatic cirrhosis complicated with portal hypertension should be regarded as a main routine choose.

关 键 词：自体脾移植 门静脉高压症 远期疗效 

分 类 号：R657.3[医药卫生—外科学]