血管紧张素转换酶抑制剂对血清钾水平的影响  

Observation on the level of serum potassium during application of angiotaensin contenting enzyme inhibitor Enalapnil

作　　者：秦家榕[1] 吴亚静[1] 徐卫刚[1] 沈瑜[1] 赵宇靖[1] 王晴[1] 

机构地区：[1]上海市皮肤病性病医院老年科,上海200443

出　　处：《上海预防医学》2007年第8期385-387,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的]观察肾功能不全的病人应用血管紧张素转换酶抑制剂（ACEI）时血清钾的水平。[方法]将病人分成肾功能正常组和肾功能不全组,二组病人都口服依那普利5mg/d。有11例因水肿同时口服安体舒通40-60mg/d。在口服前和口服后1.5个月分别作血清钾测定。在肾功能不全组的病人出现血清钾升高后改服氨氯地平5mg/d。[结果]在口服依那普利5mg/d后,肾功能不全组的血清钾水平高于肾功能正常组,改服氨氯地平5mg/d后血清钾恢复正常。Logistic回归分析显示,同时口服安体舒通和肌酐水平是引起血清钾升高的危险因素。[结论]肾功能不全组病人在口服依那普利5mg/d后血清钾高于肾功能正常组。在服用ACEI时必须监测血清钾浓度。[ Objective] To observe the level of serum potassium in patients with renal insufficiency using ACE Ⅰ Enalapril. [Methods] Renal function normal （28 cases） and renal insufficiency （23 cases） cases were enrolled for this study as two groups. They were given conventional doses enalapril 5mg/day. Because of edema 11 cases were concomitantly given spironolactone from 40mg to 60mg/day. Serum potassium were measured 1.5 month after start of enalapril treament. [ Results] The mean serum potassium elevated significantly in the group of patients with renal insufficiency. However, enalapril was discontinued and amlodipine was prescribed, the level of serum potassium returned to the normal level. Logistic regression demonstrated that spironolactone and serum creatinine were risk factors for increase in serum potassium. [ Conclusion ] The level of serum potassium is increased in patients with renal insufficiency using enalapril. It is necessary to monitor the serum concentration of potassium while using ACEIs.

关 键 词：血清钾 肾功能不全 依那普利 

分 类 号：R692[医药卫生—泌尿科学]