肺炎患者血清可溶性E、P选择素的变化及意义  

Expression and significance of serum soluble E-selectin,soluble P-selectin in patients with pneumonia

作　　者：陈愉生[1] 谢宝松[1] 林明[1] 许能銮[1] 林章树[1] 李瑞慧[1] 李鸿茹[2] 林立芳[3] 

机构地区：[1]福建省立医院呼吸内科,350001 [2]福建医科大学省立临床学院 [3]福建省心血管病重点实验室

出　　处：《福建医药杂志》2007年第4期1-2,22,共3页Fujian Medical Journal

基　　金：福建省自然科学基金资助项目(F0310043)

摘　　要：目的探讨社区获得性肺炎(community acquired pheumonia,CAP)患者血清可溶性E、P选择素(soluble E-selectin,sE-选择素,soluble P-selectin,sP-选择素)的变化及意义。方法使用ELISA双抗体夹心法动态检测25例CAP患者治疗前后及10例健康对照组血清sE-选择素、sP-选择素的水平。结果肺炎组治疗前sE-选择素水平、sP-选择素水平明显高于对照组(tsE=3.307,P<0.01;tsP=3.995,P<0.01);肺炎组治疗后,sE-选择素、sP-选择素水平均较治疗前有明显下降(tsE=5.039,P<0.01;tsP=5.707,P<0.01);治疗后两者水平与对照组相比差异均无统计学意义(tsE=1.146,P=0.26;tsP=0.070,P=0.994)。sE-选择素水平与中性粒细胞计数呈正相关(r=0.598,P<0.01),而sP-选择素与中性粒细胞计数无明显相关(r=0.029,P=0.804)。结论sE-选择素、sP-选择素参与肺炎的发生发展过程,动态检测血清sE-选择素、sP-选择素水平有助于判断CAP病情及转归。Objective To study the expression and significance of serum soluble E-selectin, soluble P-selectin in patients with community acquired pheumonia （CAP）. Methods Serum soluble E-selectin, soluble P-select was detected by ELISA as- say in 25 patients with CAP both before and after treatment as well as in 10 controls. Results Before treatment, the levels of serum soluble E-selectin, soluble P-selectin in the patients were significantly higher than those in controls （tsE = 3. 307, P〈 0.01 ; tsp = 3. 995, P〈0.01）, After treatment, the serum soluble E-selectin, soluble P-selectin levels decreased significantly （tsE=5.039, P〈0.01; tsp=5.707, P〈0.01） and were about the same with those in controls （t,E=l. 146, P=0.26; t,p= 0. 070, P=0. 994）. The levels of serum soluble E-selectin were positively associated with the number of neutrophil （r=0. 598, P〈0.01）, but the levels of soluble P-selectin were not （r=0. 029, P=0. 804）. Conclusion Both soluble E-selectin and solu- ble P-selectin play important roles in the development of pneumonia, dynamic determination of their levels will contribute to esti- mate the prognosis.

关 键 词：肺炎 可溶性E选择素 可溶性P选择素 

分 类 号：R563.1[医药卫生—呼吸系统]