塞来考昔在脊柱内固定术后镇痛中的应用  

Usage of celecoxib in treating postoperative pain of vertebral internal fixation

作　　者：丁悦[1] 黄东生[1] 马若凡[1] 李春海[1] 刘尚礼[1] 

机构地区：[1]中山大学附属第二医院骨外科,广东广州510120

出　　处：《中国新药与临床杂志》2007年第8期577-580,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：卫生部关节炎防治计划与教育基金(2004)

摘　　要：目的:研究塞来考昔在脊柱内固定术后镇痛中应用的疗效及安全性。方法:脊柱内固定手术后的病人150例,随机分为2组,每组75例,均于术后自觉疼痛开始给药。塞来考昔组予塞来考昔200 mg,po,q12h;美洛昔康组予美洛昔康7.5mg,po,qd;均治疗7d。按视觉类比量表(VAS)评价病人用药过程中的疼痛情况,并观察血压变化、监测不良反应。结果:2组病人术后,在用药后30min,VAS评分开始下降,用药2h后VAS评分下降明显(P<0.01),且镇痛作用均平稳维持12h以上。用药前后2组病人的血压无显著变化(P>0.05)。塞来考昔组和美洛昔康组不良反应发生率分别为11%和13%,主要表现为胃肠道反应,与美洛昔康相比塞来考昔的胃肠道反应相对轻微,但无显著差异,无严重不良反应发生。结论:塞来考昔可安全、有效地缓解脊柱内固定术后病人的疼痛。AIM： To study the efficacy and safety of celecoxib in treating postoperative pain of vertebral internal fixation. METHODS： One hundred and fifty patients with vertebral internal fixation were selected and randomly divided into celecoxib group （n = 75, celecoxib 200 mg, po, q12 h） or meloxicam group （n = 75, meloxicam 7.5 mg, po, qd） receiving the treatment for 7 days, respectively. Analgesic efficacy was determined by visual analogue scale （VAS） and simultaneous observation for the changes of blood pressure and the adverse reactions. RESULTS： Celecoxib can release the postoperative pain of vertebral internal fixation effectively, the effect began at 30 min after the drug administration and reach significant relief at 2 h （P 〈 0.01 ）; and sustained stably longer than 12 h. No perceivable blood pressure change was detected in both groups and the incidences of adverse reactions for celecoxib and meloxicam groups were 11% and 13 % respectively, mainly involving the gastro-intestinal tract but with no severe side complications, and with less gastro-intestinal reactions in celecoxib group in comparing with those of meloxicam group but without statistical difference. CONCLUSION： In treating postoperative pain of vertebral internal fixation, celecoxib is effective and safety.

关 键 词：塞来考昔 美洛昔康 脊柱 脊柱内固定术 

分 类 号：R971.1[医药卫生—药品]