人绝经期促性腺激素诱发排卵风险的远期随访：附21例分析  

Long term follow-up studies after treatment with gonadotropin for induction of ovulation

作　　者：杨帆[1] 邵敬於[1] 余剑敏[2] 沈智君[2] 施祖美[2] 施建平[2] 

机构地区：[1]同济大学附属第一妇婴保健院生殖中心,上海200040 [2]同济大学附属第一妇婴保健院内分泌室,上海200040

出　　处：《中国新药与临床杂志》2007年第8期593-596,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:随访早年使用促性腺激素治疗不孕症的妇女用药后的相应情况和子女情况。方法:本研究随访了1985年-1998年期间21例应用促性腺激素后得孕生子的不孕症病人的身体状况及子女情况,对所有对象进行病吏询问、妇科检查、宫颈防癌涂片、乳房检查、生殖激素和CA-125的测定以及了解是否患有子宫颈癌、子宫内膜癌、卵巢癌和乳腺癌,同时咨询子女的健康和智力情况。结果:21例病人妇科检查、防癌涂片、乳房检查、妇科B超以及CA-125均未发现异常;5例垂体性闭经者,已届绝经期年龄,血中促卵泡素(FSH)、黄体生成激素(LH)、催乳素(PRL)及雌二醇(E2)值呈低反应。本组分娩婴儿单胎13人,双胎8对,除1女婴产后8d死亡外,存活28人,现年7～23a不等,均未发现明显畸形,均健康、智力发育良好。结论:21例病人用促性腺激素促排卵治疗受孕生育后7～23a,未发现有生殖道癌肿,子代健康、智力正常。AIM： To follow-up study the health condition and next generations of infertility patients after ovulation induction with gonadotropin. METHODS： Twenty-one patients during 1985-1998 were collected and consulted with genital condition, pelvic examination, papanicolaou＇ s smear, pelvic ultrasound B scan, breast examination, reproductive hormones, CA-125 as well as their children＇ s condition. RESULTS： All those examinations did not found any abnormity in the 21 patients, of which 5 patients in menopause suffered from pituitary amenorrhea with lower values of the blood FSH, LH, E2, and PRL. There are 13 single babies and 8 twins, with 12 male and 17 female. One female infant died 8 d after born, so the total is 28 babies. All babies now aged from 7 - 23 a are healthy with normal intelligence. CONCLUSION： Any genital cancer and breast cancer do not be found in 21 infertility patients treated with gonadotropin for ovulation induction and their babies are healthy.

关 键 词：促性腺激素类 排卵诱导 随访研究 不育 

分 类 号：R714[医药卫生—妇产科学]