高效液相色谱手性流动相法拆分酮基布洛芬对映体  

Resolution of R,S ketoprofen with chiral additives as mobile phase by high performance liquid chromatography

作　　者：杨青[1] 唐瑞仁[1] 曾莎莎[1] 

机构地区：[1]中南大学化学化工学院,长沙410083

出　　处：《分析试验室》2007年第8期84-86,共3页Chinese Journal of Analysis Laboratory

摘　　要：以Lichrospher C18为分析柱,将β-环糊精、2,6-二甲基-β-环糊精、2,3,6-三甲基-β-环糊精分别作为手性流动相添加剂,系统地研究了R,S-酮基布络芬对映体在HPLC系统中的拆分。建立了以2,3,6-三甲基-β-环糊精为手性流动相添加剂分离R,S-酮基布络芬对映体方法。A reversed phase HPLC was employed for determining the enantionmer resolution of ketoprofen on Lichrospher C18 column with β-CD, DM-β-CD, TM-β-CD as chiral mobile phase additives. It was established that the chromatographic systems with TM-β-CD as chiral mobile phase additives for enantionmer resolution. Rusuhs show that the method is simple, economic and the resolution is fine.

关 键 词：高效液相色谱 手性流动相添加剂 对映体分离 

分 类 号：O657.7[理学—分析化学]