甘糖酯对肺心病患者抗氧化作用机制的探讨  

AN EXPLORATION ON THE MECHANISM OF ANTIOXIDANT EFFECT OF PGMS IN PATIENTS WITH CHRONIC COR-PUL-MONALE

作　　者：陈真如[1] 赵杏华[1] 杨山钟[1] 刘歧山[2] 管华诗[3] 李桂玲 

机构地区：[1]南京铁道医学院附属医院呼吸科,南京210009 [2]南京铁道医学院医学科学研究所 [3]青岛海洋大学,青岛266003 [4]青岛华海制药厂,青岛266003

出　　处：《中国海洋药物》1997年第1期50-52,共3页Chinese Journal of Marine Drugs

摘　　要：慢性肺心病36例,随机分为2组。甘糖酯(PGMS)组18例(男性14例,女性4例;年龄65±11y),在常规治疗基础上加用PGMS200mg于5％葡萄糖氯化钠注射液500ml中静滴,qd,共10d。并与常规治疗组18例(男性13例,女性5例,年龄67±6y)对照。结果:治疗后2组脂质过氧化物(LPO)均显著降低(P<0.01);谷胱甘肽过氧化物酶(GSH—PX)及过氧化氢酶(CAT)均显著升高(P<0.01);经组间比较,LPO的降低,CAT的升高以PGMS组更显著(P<0.05)。36 patients with chronic cor pulmonale were divided into 2 groups at random. 18 patients (M14, F4; age 65 + 11 y) received proplylene glucol mannurate sulphate (PGMS) 200 mg in 5% glucose in normal saline 500 ml iv drip qd and 18 patiants (M 13. F5? age 67+6 y) received routine treatment served as control, all were treated for 10 d. The values of glutathione peroxidase (GSH-Px), catalase (CAT) and GSH-Px/LPO (lipoper-oxide) in 2 groups were all increased distinctly, the level of LPO in 2 groups fell ( P <0. 01). But the increase of CAT and the decrease distinctly, the level of LPO in PGMS group were greater than those in routine treatment group ( P <0. 05).

关 键 词：肺心病 甘糖酯 抗氧化作用 海洋药 中医药疗法 

分 类 号：R282.770.7[医药卫生—中药学] R259.415[医药卫生—中医学]