甲状腺功能亢进症患者血清尿酸水平变化的临床分析  

Changes of serum uric acid and its clinical significance in patients with hyperthyroidism

作　　者：黄群[1] 杨香玖[1] 黄延玲[1] 

机构地区：[1]厦门大学附属中山医院内分泌科,福建厦门361004

出　　处：《临床内科杂志》2007年第8期552-553,共2页Journal of Clinical Internal Medicine

摘　　要：目的探讨甲状腺功能亢进(以下简称甲亢)患者血清尿酸浓度变化及临床意义。方法测定150例甲亢患者血清尿酸浓度并对其中50例经治疗后临床痊愈停药者复查血清尿酸水平。结果新发甲亢组患者血清尿酸浓度为(404.54±53.96)μmol/L,较正常对照组(301.19±45.48)μmol/L显著升高(P<0.01)。治疗好转组患者复查血清尿酸浓度为(293.15±42.45)μmol/L,较治疗前明显下降(P<0.01)。结论新发甲亢患者血清尿酸浓度明显升高,经治疗甲状腺功能恢复正常后血清尿酸浓度可显著下降。表明甲亢作为一种消耗性疾病,其高代谢状态可导致尿酸代谢异常,使血尿酸浓度升高。Objective To investigate clinical significance of changes of serum uric acid in patients with hyperthyroidism. Methods Serum uric acid were measured in 150 patients with hyperthyroidism. After treatment, the blood uric acid were rechecked in 50 patients who were fully recovered and stopped drugs taking. Results As compared with normal controls, the concentration of patients with hyperthyroidism is significantly increased （404.54 ＋ 53.96 μmol/L vs301.19 ＋ 45.48 μmol/L, P 〈 0.01 ）. After treatment the concentration of serum uric acid in therapy group is 293.15 ＋ 42.45 μmol/L. It was significantly lower than that in patients before treatment （ P 〈 0. 001 ）. Conclusion The concentration of serum uric acid is increased in patients with hyperthyriodsim. After therapy it can decreased significantly with the recovery of the desease.

关 键 词：尿酸 甲状腺功能亢进症 甲亢 

分 类 号：R581.1[医药卫生—内分泌]