红细胞输注对凝血功能的影响  

The effect of erythrocyte transfusions on haemostatic function

作　　者：梁晓林[1] 槐庆元[2] 王仲泉[1] 

机构地区：[1]首都医科大学附属北京友谊医院输血科,100050 [2]首都医科大学附属北京友谊医院麻醉科,100050

出　　处：《北京医学》2007年第8期495-496,共2页Beijing Medical Journal

摘　　要：目的探讨红细胞输注量对受血者凝血功能的影响。方法回顾性调查30例择期手术患者输入红细胞后6h内主要凝血指标的变化和临床出血情况。根据输注红细胞量分为6U组、10U组和20U组,每组10例,输注前检测各组主要凝血指标均在正常范围。结果患者输入红细胞6U、10U、20U后,血小板(PLT)分别为(166±50)×109/L﹑(85±25×)109/L﹑(30±20)×109/L;凝血酶原时间(PT)分别为(13±2)s﹑(16.2±2.2)s﹑(22.6±2.8)s;活化部分的凝血活酶时间(APTT)分别为(26.0±8.4)s﹑(49±11)s﹑(69.0±7.6)s;纤维蛋白原(Fg)含量分别为(3.1±0.9)g/L﹑(1.9±0.6)g/L、(0.8±0.5)g/L,各组间四项凝血指标的比较均有非常显著性差异(P﹤0.01);临床出血情况分别为渗血不明显、渗血明显、渗血十分明显。结论输入红细胞﹥10U时应立即补充相应的凝血成分,以减少出血事件的发生。Objective To observe the effect of erythrocyte transfusion volume on haemostatic function. Methods The changes of haemostatic function and hemorrhagic symptoms of 30 patients were investigated retrospectly 6 hours after erythrocyte transfusion. All patients were divided into the 6U,10U and 20U group based on the volume of erythrocyte transfusion. The cases were in each group. Before erythrocyte transfusions. The basal haemostatic examination results of all patients were normal and no significant difference （P 〉 0.05）was observed among the three groups. Results Average value of PLT, PT, APTT and Fibrinogenin 6U,10U and 20U group was （166±50）×10^9/L, （85±25）×10^9/L, （30±20）×10^9/L; （13±2）s, （16.2±2.2）s, （22.6±2.8）s; （26.0±8.4）s, （49±11）s, （69.0±7.6）s; （3.1±0.9）g/L, （1.9±0.6）g/L, （0.8±0.5）g/L, respectively. Significant difference （P 〈 0.01 ）was observed in all primary haemostatic examination results among 3 groups. Clinical hemorrhagic symptoms of 6U, 10U and 20U group were not-obvious, obvious and evident. Conclusions When erythrocyte transfusion volume exceeds 10u, coagulation factors should be replenished to reduce the events of hemorrhage.

关 键 词：红细胞 凝血功能 输注 

分 类 号：R457[医药卫生—治疗学]