血清IGF-Ⅱ在肝癌患者TACE介入治疗前后的变化  

Clinical Significance of Serum Insulin-like Growth Factor-Ⅱ Changes in Patients with Hepatocellular Carcinoma before and after Transcatheter Arterial Chemoembolization

作　　者：任宗海[1] 虞希祥[2] 李荣洲[1] 林讷[1] 季婷婷[1] 蔡积武[1] 

机构地区：[1]浙江省温州医学院附属第三医院消化内科,温州325200 [2]浙江省温州医学院附属第三医院介入科,温州325200

出　　处：《中国中西医结合外科杂志》2007年第4期339-341,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探讨原发性肝癌患者血清胰岛素样生长因子-Ⅱ(IGF-Ⅱ)在肝动脉化疗栓塞术(TACE)介入治疗前、后水平变化的临床意义。方法:原发性肝癌患者33例,健康体检者48例,采用放射免疫法,测定健康体检者及介入治疗前后的肝癌患者血清IGF-Ⅱ水平。结果:介入治疗前、后血清IGF-Ⅱ水平均显著高于正常对照组(P<0·001)。其中治疗有效组20例,介入治疗前和治疗后血清IGF-Ⅱ水平的比较,显示第2次TACE治疗以后血清IGF-II水平逐渐降低,有统计学显著意义(P<0·01或P<0·001)。无效组13例,介入治疗前与治疗后血清IGF-Ⅱ水平的比较差异无统计学意义(P>0·05)。结论:多次TACE可降低原发性肝癌患者治疗有效者血清IGF-Ⅱ的水平,检测血清IGF-Ⅱ可作为诊断原发性肝癌及评价TACE疗效、复发、转移及肝癌预后的指标。Objective To evaluate clinical significance of serum insulin- like growth factor- Ⅱ（ IGF- Ⅱ） changes in patients with hepatocellular carcinoma （HCC） receiving transcatheter arterial chemoembolization（TACE） Methods The serum levels of IGF-Ⅱ in 33 cases of HCC before and after TACE and 48 normal controls were measured by radioimmunoassay and compared. Results The serum levels of IGF - Ⅱin HCC group were higher than those in control group（ P 〈 0.001 ）. After TACE 20 cases were effective among 33 cases of HCC, the serum levels of IGF-Ⅱ in them dropped down markedly after TACE （ P 〈 0.01 or P 〈 0.001 ） ; in the other 13 cases it was inefficient, the serum levels of IGF -Ⅱ in them did not change after TACE （ P 〉 0.05）. Conclusion The sermn level of IGF -Ⅱ can be reduced by TACE and may be used as a new marker of diagnosing HCC and evaluating the efficacy of TACE in HCC patients.

关 键 词：肝细胞肝癌 血清胰岛素样生长因子-Ⅱ 肝动脉化疗栓塞术 

分 类 号：R512.62[医药卫生—内科学]